Are uric acid levels different from healthy subjects in bipolar affective disorder and schizophrenia?: Relationship between clinical improvement and episode severity in male patients/Urik asit duzeyleri iki uclu bozukluk ve sizofrenide saglikli bireylerden farkli midir?: Erkek cinsiyette klinik iyilesme ve donem siddeti ile iliskisi

Introduction: Purinergic system dysfunction has been shown both in patients with bipolar disorder (BD) and those with schizophrenia. The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from hea...

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Published in:Noro-Psikiyatri Arsivi 2014-09, Vol.51 (3), p.229
Main Authors: Gultekin, Bulent Kadri, Kesebir, Sermin, Gul Kabak, Sevgi, Ergun, Ferzan Fikret, Tatlidil Yaylaci, Elif
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Bipolar disorder
Drug therapy
Health aspects
Risk factors
Schizophrenia
Uric acid
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Kesebir, Sermin
Gul Kabak, Sevgi
Ergun, Ferzan Fikret
Tatlidil Yaylaci, Elif
description Introduction: Purinergic system dysfunction has been shown both in patients with bipolar disorder (BD) and those with schizophrenia. The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from healthy male subjects. Secondly to assess whether uric acid levels in both patient groups correlate with episode severity and if a decrease in uric acid levels correlate with clinical improvement. Method: A total of 55 BD patients with manic episode and 59 schizophrenic patients with psychotic relapse were evaluated at baseline and at weeks 1, 2, 3 using the Young Mania Rating Scale (YMRS) and the Positive and Negative Syndrome Scale (PANSS), and their plasma uric acid levels were measured. 60 age-matched healthy males without history of any previous or current psychiatric diagnosis and treatment constituted the control group. In order to determine plasma uric acid levels, blood samples were centrifuged at 3000 x g for 15 minutes, stored at -80[degrees]C and measured in milligrams per deciliter. Results: Uric acid levels in both patient groups with manic episode and psychotic relapse were found higher than in healthy controls (f=6.122, p=0.027). The difference between repeated measurements of uric acid levels in BD patient group was found to be between baseline and first week measurements (after Bonferroni correction) (p
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The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from healthy male subjects. Secondly to assess whether uric acid levels in both patient groups correlate with episode severity and if a decrease in uric acid levels correlate with clinical improvement. Method: A total of 55 BD patients with manic episode and 59 schizophrenic patients with psychotic relapse were evaluated at baseline and at weeks 1, 2, 3 using the Young Mania Rating Scale (YMRS) and the Positive and Negative Syndrome Scale (PANSS), and their plasma uric acid levels were measured. 60 age-matched healthy males without history of any previous or current psychiatric diagnosis and treatment constituted the control group. In order to determine plasma uric acid levels, blood samples were centrifuged at 3000 x g for 15 minutes, stored at -80[degrees]C and measured in milligrams per deciliter. Results: Uric acid levels in both patient groups with manic episode and psychotic relapse were found higher than in healthy controls (f=6.122, p=0.027). The difference between repeated measurements of uric acid levels in BD patient group was found to be between baseline and first week measurements (after Bonferroni correction) (p&lt;0.001). No correlation was found between YMRS and PANSS scores and uric acid levels at 4 assessment times. Conclusion: Uric acid levels in male BD and schizophrenia patients with manic episode and psychotic relapse were similar with each other, and higher than in healthy males. No correlation was found between uric acid levels and episode severity in both groups. However, for patients with BD, a decrease in uric acid levels between baseline and first week seems to be correlated with clinical improvement. (Archives of Neuropsychiatry 2014; 51:229-232) Key words: Bipolar disorder, schizophrenia, uric acid Giris: Purinerjik sistem isleyisindeki bozulma hem iki uclu bozukluk (IUB), hem sizofreni tanili olgularda gosterilmistir. Bu calismanin amaci IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeylerinin, saglikli erkeklerden farklilasip farklilasmadiginin arastirilmasidir. Ikinci olarak her iki tani grubunda urik asit duzeylerinin donem siddeti ile, urik asit duzeylerindeki azalmanin klinik iyilesme ile iliski gosterip gostermediginin incelenmesidir. Yontem: Bu amacla 55 IUB, 59 sizofreni tanili olgu manik donem ve psikotik alevlenme doneminin basinda, 1., 2. ve 3. haftada YMDO ve PANSS ile degerlendirilmis, plazma urik asit duzeyleri olculmustur. Kontrol grubu diger iki grupla yas ortalamasi benzer, onceki tani ve tedavi oykusu olmayan ve simdiki psikiyatrik yakinmasi bulunmayan 60 saglikli erkektir. Plazma urik asit duzeyleri 3000 devirli santrifujde 15 dakika cevrilerek, -80[degrees]C, mg/ dl cinsinden kaydedilmistir. Bulgular: Hem IUB hem sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri saglikli erkeklerden yuksek bulundu (f = 6.122, p = 0.027). IUB tanili erkeklerde yinelenen olcumler arasindaki fark (Bonferroni duzeltmesi ile) baslangic ile 1. hafta urik asit duzeyleri arasinda saptandi (p&lt;0.001). Her dort olcum icin YMDO ve PANNS puanlari ile urik asit duzeyleri arasinda bir korelasyon gosterilemedi. Sonuc: IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri birbiri ile benzer olup, saglikli erkeklerden yuksektir. Her iki grupta urik asit duzeyleri ile donem siddeti arasinda bir baginti bulunmamistir. Ancak IUB tanili olgularda urik asit duzeylerinde baslangic ve birinci hafta arasindaki azalma, klinik iyilesme ile iliskili gorunmektedir. (Noropsikiyatri Arsivi 2014; 51:229-232) Anahtar kelimeler: Iki uclu bozukluk, sizofreni, urik asit</description><identifier>ISSN: 1300-0667</identifier><identifier>DOI: 10.4274/npa.y6827</identifier><language>eng</language><publisher>AVES</publisher><subject>Bipolar disorder ; Drug therapy ; Health aspects ; Risk factors ; Schizophrenia ; Uric acid</subject><ispartof>Noro-Psikiyatri Arsivi, 2014-09, Vol.51 (3), p.229</ispartof><rights>COPYRIGHT 2014 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Gultekin, Bulent Kadri</creatorcontrib><creatorcontrib>Kesebir, Sermin</creatorcontrib><creatorcontrib>Gul Kabak, Sevgi</creatorcontrib><creatorcontrib>Ergun, Ferzan Fikret</creatorcontrib><creatorcontrib>Tatlidil Yaylaci, Elif</creatorcontrib><title>Are uric acid levels different from healthy subjects in bipolar affective disorder and schizophrenia?: Relationship between clinical improvement and episode severity in male patients/Urik asit duzeyleri iki uclu bozukluk ve sizofrenide saglikli bireylerden farkli midir?: Erkek cinsiyette klinik iyilesme ve donem siddeti ile iliskisi</title><title>Noro-Psikiyatri Arsivi</title><description>Introduction: Purinergic system dysfunction has been shown both in patients with bipolar disorder (BD) and those with schizophrenia. The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from healthy male subjects. Secondly to assess whether uric acid levels in both patient groups correlate with episode severity and if a decrease in uric acid levels correlate with clinical improvement. Method: A total of 55 BD patients with manic episode and 59 schizophrenic patients with psychotic relapse were evaluated at baseline and at weeks 1, 2, 3 using the Young Mania Rating Scale (YMRS) and the Positive and Negative Syndrome Scale (PANSS), and their plasma uric acid levels were measured. 60 age-matched healthy males without history of any previous or current psychiatric diagnosis and treatment constituted the control group. In order to determine plasma uric acid levels, blood samples were centrifuged at 3000 x g for 15 minutes, stored at -80[degrees]C and measured in milligrams per deciliter. Results: Uric acid levels in both patient groups with manic episode and psychotic relapse were found higher than in healthy controls (f=6.122, p=0.027). The difference between repeated measurements of uric acid levels in BD patient group was found to be between baseline and first week measurements (after Bonferroni correction) (p&lt;0.001). No correlation was found between YMRS and PANSS scores and uric acid levels at 4 assessment times. Conclusion: Uric acid levels in male BD and schizophrenia patients with manic episode and psychotic relapse were similar with each other, and higher than in healthy males. No correlation was found between uric acid levels and episode severity in both groups. However, for patients with BD, a decrease in uric acid levels between baseline and first week seems to be correlated with clinical improvement. (Archives of Neuropsychiatry 2014; 51:229-232) Key words: Bipolar disorder, schizophrenia, uric acid Giris: Purinerjik sistem isleyisindeki bozulma hem iki uclu bozukluk (IUB), hem sizofreni tanili olgularda gosterilmistir. Bu calismanin amaci IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeylerinin, saglikli erkeklerden farklilasip farklilasmadiginin arastirilmasidir. Ikinci olarak her iki tani grubunda urik asit duzeylerinin donem siddeti ile, urik asit duzeylerindeki azalmanin klinik iyilesme ile iliski gosterip gostermediginin incelenmesidir. Yontem: Bu amacla 55 IUB, 59 sizofreni tanili olgu manik donem ve psikotik alevlenme doneminin basinda, 1., 2. ve 3. haftada YMDO ve PANSS ile degerlendirilmis, plazma urik asit duzeyleri olculmustur. Kontrol grubu diger iki grupla yas ortalamasi benzer, onceki tani ve tedavi oykusu olmayan ve simdiki psikiyatrik yakinmasi bulunmayan 60 saglikli erkektir. Plazma urik asit duzeyleri 3000 devirli santrifujde 15 dakika cevrilerek, -80[degrees]C, mg/ dl cinsinden kaydedilmistir. Bulgular: Hem IUB hem sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri saglikli erkeklerden yuksek bulundu (f = 6.122, p = 0.027). IUB tanili erkeklerde yinelenen olcumler arasindaki fark (Bonferroni duzeltmesi ile) baslangic ile 1. hafta urik asit duzeyleri arasinda saptandi (p&lt;0.001). Her dort olcum icin YMDO ve PANNS puanlari ile urik asit duzeyleri arasinda bir korelasyon gosterilemedi. Sonuc: IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri birbiri ile benzer olup, saglikli erkeklerden yuksektir. Her iki grupta urik asit duzeyleri ile donem siddeti arasinda bir baginti bulunmamistir. Ancak IUB tanili olgularda urik asit duzeylerinde baslangic ve birinci hafta arasindaki azalma, klinik iyilesme ile iliskili gorunmektedir. (Noropsikiyatri Arsivi 2014; 51:229-232) Anahtar kelimeler: Iki uclu bozukluk, sizofreni, urik asit</description><subject>Bipolar disorder</subject><subject>Drug therapy</subject><subject>Health aspects</subject><subject>Risk factors</subject><subject>Schizophrenia</subject><subject>Uric acid</subject><issn>1300-0667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkc1r3DAQxV1ooWnaQ_-DgUJvu7Hlz-2lLCFtA6GFkp6DLI3WE8kfSPIG71_fcdJDAkUHwfDem5_0kuRjlm4LURcXwyS3S9WI-nVyluVpukmrqn6bvAvhPk2rvMnqs1c_9x5h9qRAKtLg8IgugCZj0OMQwfixhw6li90CYW7vUcUANEBL0-ikB8lKFemIbAqj18ijQUNQHZ3GqeMQkl-_wG90MtI4hI4maDE-IA6gHA2kpAPqJz8esV83rm6cOEsjBMbxFJd1YS8dwsQhLAoXfzxZkIEi6PmEi2MZkCWYlZuhHU-zdbMFpgqMYVaKNU4eHFlHDO8fPZohjPTrqCdNnkGvvEULioZAC8aIYFdIC7SQw9DjmqnHAXtO1hojr2UuchQsBXqfvDHSBfzw7z5Pbr9d3V7-2Nz8-n59ub_ZHHaN2JSYlU1RiloIscubpinzncmKVst2Z9JKV6ZIMa1qbJtCNlKUmRSVyDW3qqWRIj9PPj3FHvhT7mgwY_RS9RTU3b5IRVPXebGqtv9R8dHYk-I3GEZ_afj8zPDUehjd_Fjcc-Ff3j_Jxg</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Gultekin, Bulent Kadri</creator><creator>Kesebir, Sermin</creator><creator>Gul Kabak, Sevgi</creator><creator>Ergun, Ferzan Fikret</creator><creator>Tatlidil Yaylaci, Elif</creator><general>AVES</general><scope/></search><sort><creationdate>20140901</creationdate><title>Are uric acid levels different from healthy subjects in bipolar affective disorder and schizophrenia?: Relationship between clinical improvement and episode severity in male patients/Urik asit duzeyleri iki uclu bozukluk ve sizofrenide saglikli bireylerden farkli midir?: Erkek cinsiyette klinik iyilesme ve donem siddeti ile iliskisi</title><author>Gultekin, Bulent Kadri ; Kesebir, Sermin ; Gul Kabak, Sevgi ; Ergun, Ferzan Fikret ; Tatlidil Yaylaci, Elif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g982-5e158452722293888539f14bdab9f06d6f40e067eb84a8a251a2623d427dafa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bipolar disorder</topic><topic>Drug therapy</topic><topic>Health aspects</topic><topic>Risk factors</topic><topic>Schizophrenia</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gultekin, Bulent Kadri</creatorcontrib><creatorcontrib>Kesebir, Sermin</creatorcontrib><creatorcontrib>Gul Kabak, Sevgi</creatorcontrib><creatorcontrib>Ergun, Ferzan Fikret</creatorcontrib><creatorcontrib>Tatlidil Yaylaci, Elif</creatorcontrib><jtitle>Noro-Psikiyatri Arsivi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gultekin, Bulent Kadri</au><au>Kesebir, Sermin</au><au>Gul Kabak, Sevgi</au><au>Ergun, Ferzan Fikret</au><au>Tatlidil Yaylaci, Elif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are uric acid levels different from healthy subjects in bipolar affective disorder and schizophrenia?: Relationship between clinical improvement and episode severity in male patients/Urik asit duzeyleri iki uclu bozukluk ve sizofrenide saglikli bireylerden farkli midir?: Erkek cinsiyette klinik iyilesme ve donem siddeti ile iliskisi</atitle><jtitle>Noro-Psikiyatri Arsivi</jtitle><date>2014-09-01</date><risdate>2014</risdate><volume>51</volume><issue>3</issue><spage>229</spage><pages>229-</pages><issn>1300-0667</issn><abstract>Introduction: Purinergic system dysfunction has been shown both in patients with bipolar disorder (BD) and those with schizophrenia. The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from healthy male subjects. Secondly to assess whether uric acid levels in both patient groups correlate with episode severity and if a decrease in uric acid levels correlate with clinical improvement. Method: A total of 55 BD patients with manic episode and 59 schizophrenic patients with psychotic relapse were evaluated at baseline and at weeks 1, 2, 3 using the Young Mania Rating Scale (YMRS) and the Positive and Negative Syndrome Scale (PANSS), and their plasma uric acid levels were measured. 60 age-matched healthy males without history of any previous or current psychiatric diagnosis and treatment constituted the control group. In order to determine plasma uric acid levels, blood samples were centrifuged at 3000 x g for 15 minutes, stored at -80[degrees]C and measured in milligrams per deciliter. Results: Uric acid levels in both patient groups with manic episode and psychotic relapse were found higher than in healthy controls (f=6.122, p=0.027). The difference between repeated measurements of uric acid levels in BD patient group was found to be between baseline and first week measurements (after Bonferroni correction) (p&lt;0.001). No correlation was found between YMRS and PANSS scores and uric acid levels at 4 assessment times. Conclusion: Uric acid levels in male BD and schizophrenia patients with manic episode and psychotic relapse were similar with each other, and higher than in healthy males. No correlation was found between uric acid levels and episode severity in both groups. However, for patients with BD, a decrease in uric acid levels between baseline and first week seems to be correlated with clinical improvement. (Archives of Neuropsychiatry 2014; 51:229-232) Key words: Bipolar disorder, schizophrenia, uric acid Giris: Purinerjik sistem isleyisindeki bozulma hem iki uclu bozukluk (IUB), hem sizofreni tanili olgularda gosterilmistir. Bu calismanin amaci IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeylerinin, saglikli erkeklerden farklilasip farklilasmadiginin arastirilmasidir. Ikinci olarak her iki tani grubunda urik asit duzeylerinin donem siddeti ile, urik asit duzeylerindeki azalmanin klinik iyilesme ile iliski gosterip gostermediginin incelenmesidir. Yontem: Bu amacla 55 IUB, 59 sizofreni tanili olgu manik donem ve psikotik alevlenme doneminin basinda, 1., 2. ve 3. haftada YMDO ve PANSS ile degerlendirilmis, plazma urik asit duzeyleri olculmustur. Kontrol grubu diger iki grupla yas ortalamasi benzer, onceki tani ve tedavi oykusu olmayan ve simdiki psikiyatrik yakinmasi bulunmayan 60 saglikli erkektir. Plazma urik asit duzeyleri 3000 devirli santrifujde 15 dakika cevrilerek, -80[degrees]C, mg/ dl cinsinden kaydedilmistir. Bulgular: Hem IUB hem sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri saglikli erkeklerden yuksek bulundu (f = 6.122, p = 0.027). IUB tanili erkeklerde yinelenen olcumler arasindaki fark (Bonferroni duzeltmesi ile) baslangic ile 1. hafta urik asit duzeyleri arasinda saptandi (p&lt;0.001). Her dort olcum icin YMDO ve PANNS puanlari ile urik asit duzeyleri arasinda bir korelasyon gosterilemedi. Sonuc: IUB ve sizofreni tanili erkek olgularda manik donem ve psikotik alevlenme sirasindaki urik asit duzeyleri birbiri ile benzer olup, saglikli erkeklerden yuksektir. Her iki grupta urik asit duzeyleri ile donem siddeti arasinda bir baginti bulunmamistir. Ancak IUB tanili olgularda urik asit duzeylerinde baslangic ve birinci hafta arasindaki azalma, klinik iyilesme ile iliskili gorunmektedir. (Noropsikiyatri Arsivi 2014; 51:229-232) Anahtar kelimeler: Iki uclu bozukluk, sizofreni, urik asit</abstract><pub>AVES</pub><doi>10.4274/npa.y6827</doi></addata></record>
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subjects Bipolar disorder
Drug therapy
Health aspects
Risk factors
Schizophrenia
Uric acid
title Are uric acid levels different from healthy subjects in bipolar affective disorder and schizophrenia?: Relationship between clinical improvement and episode severity in male patients/Urik asit duzeyleri iki uclu bozukluk ve sizofrenide saglikli bireylerden farkli midir?: Erkek cinsiyette klinik iyilesme ve donem siddeti ile iliskisi
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