ZSM-5 Catalyzed Solvent Free Ecofriendly Synthesis of Substituted Pyrimidine Derivatives

Azeolite ZSM-5 catalyzed simple, one-pot solvent-free, cost-effective and environmental benign protocol for the synthesis of dihydropyrimidines (DHPMs) have been developed. Aseries of substituted 1,4-DHPM derivatives have been synthesized by one-pot Biginelli type cyclocondensation of ethylacetoacet...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-01, Vol.48 (10), p.679-682
Main Authors: Bajaj, S. D., Mahodaya, O. A., Tekade, P. V.
Format: Article
Language:English
Subjects:
Aldehydes
Antifungal agents
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyrimidines
Zeolites
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Summary:Azeolite ZSM-5 catalyzed simple, one-pot solvent-free, cost-effective and environmental benign protocol for the synthesis of dihydropyrimidines (DHPMs) have been developed. Aseries of substituted 1,4-DHPM derivatives have been synthesized by one-pot Biginelli type cyclocondensation of ethylacetoacetate, aromatic/heteroaromatic aldehydes, and urea/thiourea with a catalytic amount of zeolite under solvent-free protocol in a sufficiently high yield. The catalyst is recyclable and can be used repeatedly.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1170-7