Clinico-pathology, hematology, and biochemistry responses toward Pasteurella multocida Type B: 2 via oral and subcutaneous route

• Published in: Veterinary World 2015-06, Vol.8 (6), p.783
• Main Authors: Chung, Eric Lim Teik, Abdullah, Faez Firdaus Jesse, Adamu, Lawan, Marza, Ali Dhiaa, Ibrahim, Hayder Hamzah, Zamri-Saad, Mohd, Haron, Abdul Wahid, Saharee, Abdul Aziz, Lila, Mohd Azmi Mohd, Omar, Abdul Rahman, Bakar, Md Zuki Abu, Norsidin, Mohd Jefri
• Format: Article
• Language: English
• Subjects: Development and progression; Health aspects; Immune response; Medical research; Pasteurella infections; Precision medicine
• ISSN: 0972-8988
• DOI: 10.14202/vetworld.2015.783-792

Background: Pasteurella multocida a Gram-negative bacterium has been identified as the causative agent of many economically important diseases in a wide range of hosts. Hemorrhagic septicemia is a disease caused by P multocida serotype B:2 and E:2. The organism causes acute, a highly fatal septicemic disease with high morbidity and mortality in cattle and more susceptible in buffaloes. Therefore, the aim of this study was to investigate the clinical signs, blood parameters, post mortem and histopathology changes caused by P. multocida Type B:2 infections initiated through the oral and subcutaneous routes. Methods: Nine buffalo heifers were divided equally into 3 treatment groups. Group 1 was inoculated orally with 10 ml of phosphate buffer saline; Groups 2 and 3 were inoculated with 10 ml of 1012 colony forming unit of P multocida Type B:2 subcutaneously and orally respectively. Results: There was a significant difference (p