Synthesis and Antioxidant Activity of Quercetin Ethers

Quercetin (Q) methyl ethers were synthesized from CH 3 I under various conditions. The principal products from the reactions of Q with alkylhalides (CH 3 I, C 4 H 9 Br) in DMF were 3,7,4′-tri-O-alkyl ethers. The structures of the products were confirmed by PMR and 13 C NMR spectra. The antioxidant a...

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Bibliographic Details
Published in:Chemistry of natural compounds 2015-09, Vol.51 (5), p.851-855
Main Authors: Karimova, E. R., Baltina, L. A., Spirikhin, L. V., Kondratenko, R. M., Farkhutdinov, R. R., Petrova, I. V.
Format: Article
Language:English
Subjects:
Antioxidants (Nutrients)
Dimethylformamide
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Rutin
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Summary:Quercetin (Q) methyl ethers were synthesized from CH 3 I under various conditions. The principal products from the reactions of Q with alkylhalides (CH 3 I, C 4 H 9 Br) in DMF were 3,7,4′-tri-O-alkyl ethers. The structures of the products were confirmed by PMR and 13 C NMR spectra. The antioxidant activity of Q tetra- and tri-O-methyl ethers was demonstrated by chemiluminescence in model systems generating active oxygen species and promoting lipid peroxidation.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-015-1432-3