Efficient synthesis, antioxidant and antimicrobial profiles of 2-- 1,3,4,2λ.sup.5-dioxazaphosphinin-2-ones

Synthesis of 5,6-diphenyl-6H-1,3,4,2λ.sup.5-dioxazaphosphinin-2-ones having an amino substituent at phosphorus atom has been accomplished in two steps. It involves the preparation of 2-chloro intermediate and its subsequent reaction with various aromatic or heterocyclic amines in dry tetrahydrofuran...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2015-02, Vol.51 (2), p.194
Main Authors: Rao, K. Uma Maheswara, Sudha, S. Santhi, Krishna, B. Satheesh, Ramamohan, P, Reddy, C. Suresh
Format: Article
Language:English
Subjects:
Antioxidants
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Summary:Synthesis of 5,6-diphenyl-6H-1,3,4,2λ.sup.5-dioxazaphosphinin-2-ones having an amino substituent at phosphorus atom has been accomplished in two steps. It involves the preparation of 2-chloro intermediate and its subsequent reaction with various aromatic or heterocyclic amines in dry tetrahydrofuran and triethylamine at reflux temperature. These compounds were characterized by IR, .sup.1H, .sup.13C, and .sup.31P NMR spectroscopy and mass spectrometry, and elemental analysis. All the title compounds were screened for antioxidant properties by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay, reducing power assay, and lipid peroxidation assay. The tested compounds exhibited potent dose-dependent in vitro antioxidant activity, as well as a significant antimicrobial activity.
ISSN:0009-3122
DOI:10.1007/s10593-015-1680-y