Synthesis and cytotoxic activity of [benzo[b][1,4]oxazepino[7,6,5-de]quinolin-2-yl]-1,3-tropolones

We describe the synthesis of previously unknown halogenated derivatives of 2-(benzo[ b ][1,4]oxazepino[7,6,5- de ]quinolin-2-yl)-1,3-tropolone. The MTT colorimetric assay was used to detect anticancer activity and inhibition of human epidermoid carcinoma (KB human epithelial carcinoma cell line) gro...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2015-03, Vol.51 (3), p.291-294
Main Authors: Bang, Duong Nghia, Sayapin, Yurii A., Lam, Hoang, Duc, Nguyen Dang, Komissarov, Vitaly N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
Quinoline
Telomerase
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Summary:We describe the synthesis of previously unknown halogenated derivatives of 2-(benzo[ b ][1,4]oxazepino[7,6,5- de ]quinolin-2-yl)-1,3-tropolone. The MTT colorimetric assay was used to detect anticancer activity and inhibition of human epidermoid carcinoma (KB human epithelial carcinoma cell line) growth by 9,11-di( tert- butyl)-5-chloro-2,4-dimethyl-7 Н -enzo[ b ][1,4]oxazepino[7,6,5- de ]quinoline at IC 50 93.7 μg/ml, and human breast carcinoma (MCF-7 cell line) growth by 2-[7-acetyl-9,11-di( tert- butyl)-5-chloro-4-methylbenzo[ b ][1,4]-oxazepino[7,6,5- de ]quinolin-2-yl]-5,6,7-trichloro-1,3-tropolone at IC 50 12.96 μg/ml.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-015-1697-2