Polyphenolic Metabolites from Iris pseudacorus Roots

Five known isoflavonoids ( 6 – 8 , 11 , 16 ), one flavonoid ( 14 ), four hydroxybenzoic acids ( 1 – 4 ), and a new 7-O- β -D-glucopyranoside of 5,7-dihydroxy-2′,6-dimethoxyisoflavone ( 5 ) were isolated from Iris pseudacorus roots and identified. The polyphenol contents in stems and roots of this pl...

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Bibliographic Details
Published in:Chemistry of natural compounds 2015-05, Vol.51 (3), p.451-455
Main Authors: Tarbeeva, D. V., Fedoreev, S. A., Veselova, M. V., Kalinovskii, A. I., Gorovoi, P. G., Vishchuk, O. S., Ermakova, S. P., Zadorozhnyi, P. A.
Format: Article
Language:English
Subjects:
Colorectal cancer
Isoflavones
Medicine
Metabolites
Organic Chemistry
Pharmacy
Plant Sciences
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Summary:Five known isoflavonoids ( 6 – 8 , 11 , 16 ), one flavonoid ( 14 ), four hydroxybenzoic acids ( 1 – 4 ), and a new 7-O- β -D-glucopyranoside of 5,7-dihydroxy-2′,6-dimethoxyisoflavone ( 5 ) were isolated from Iris pseudacorus roots and identified. The polyphenol contents in stems and roots of this plant were determined. The effect of 6 , 8 , 9 , 11 , 15 , and 16 on the growth of colonies of HT-29 human colon carcinoma cells was studied. It was shown that trans-3-hydroxy-5,7-dimethoxyflavanone ( 9 ) exhibited pronounced inhibition of tumor-cell colony formation at a dose of 25 μM.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-015-1313-9