BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo E.sup.-/- Mice

Inflammation plays a fundamental role in the inception and development of atherosclerosis (ATH). Mechanisms of inflammation include the infiltration of monocytes into the injured area and subsequent differentiation into either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. We h...

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Bibliographic Details
Published in:PloS one 2016-01, Vol.11 (1), p.e0147897
Main Authors: Singla, Dinender K, Singla, Reetu, Wang, Jing
Format: Article
Language:English
Subjects:
Analysis
Atherosclerosis
Bone morphogenetic proteins
Care and treatment
Development and progression
Genetic aspects
Macrophages
Physiological aspects
Online Access:Get full text
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Summary:Inflammation plays a fundamental role in the inception and development of atherosclerosis (ATH). Mechanisms of inflammation include the infiltration of monocytes into the injured area and subsequent differentiation into either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. We have previously published data suggesting bone morphogenetic protein-7 (BMP-7) enhances M2 macrophage differentiation and anti-inflammatory cytokine secretion in vitro. In this regard, we hypothesized BMP-7 would inhibit plaque formation in an animal model of ATH through monocytic plasticity mediation. ATH was generated in male and female Apo E.sup.-/- mice via partial left carotid artery (PLCA) ligation and mice were divided into 3 groups: Sham, PLCA, and PLCA+BMP-7 (200ug/kg; i.v.). Our data suggest that BMP-7 inhibits plaque formation and increases arterial systolic velocity. Furthermore, we report inhibition of monocyte infiltration and a decrease in associated pro-inflammatory cytokines (MCP-1, TNF-[alpha], and IL-6) in the PLCA+BMP-7 mice. In contrast, our data suggest a significant (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0147897