Avian IgY antibodies: characteristics and applications in immunodiagnostic/ Anticorpos IgY aviario: caracteristicas e aplicacoes em imunodiagnostico

Immunoglobulin Y (IgY) is the major antibody isotype in birds, reptiles, amphibia, and lungfish, playing a similar biological role as mammal IgG. Due to its phylogenetic distance, immune diversification and presence in the egg yolk, IgY provide a number of advantages in immunodiagnostic compared to...

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Bibliographic Details
Published in:Ciência rural 2014-01, Vol.44 (1), p.153
Main Authors: Munhoz, Livia Silveira, Vargas, Gilberto D'Avila, Fischer, Geferson, de Lima, Marcelo, Esteves, Paulo Augusto, Hubner, Silvia de Oliveira
Format: Article
Language:Spanish
Subjects:
Animal experimentation
Animal welfare
Birds
Immunoglobulin G
Phylogeny
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Summary:Immunoglobulin Y (IgY) is the major antibody isotype in birds, reptiles, amphibia, and lungfish, playing a similar biological role as mammal IgG. Due to its phylogenetic distance, immune diversification and presence in the egg yolk, IgY provide a number of advantages in immunodiagnostic compared to IgG from mammals. Moreover, IgY production is in agreement with international efforts to reduce, refine and if possible, to replace animals in experimentation, contributing substantially in favor of animal welfare. This article presents an overview about structural and functional features, production and applications of IgY in immunodiagnostic, as well as the advantages of chicken antibodies use. Key words: egg yolk antibody, immunodiagnostic s, immunoglobulin Y, polyclonal antibodies. A imunoglobulina Y (IgY) e a classe de anticorpos de maior importancia em aves, repteis, anfibios e peixes pulmonados, desempenhando um papel semelhante a IgG de mamiferos. Devido a sua distancia filogenetica, mecanismos de diversificacao imune e presenca na gema do ovo, IgY proporciona uma serie de vantagens em imunodiagnostico, quando comparada a IgG de mamiferos. Alem disso, esse metodo alternativo de producao de anticorpo esta de acordo com os esforcos internacionais para reduzir, refinar e, se possivel, substituir animais em experimentacao, contribuindo substancialmente a favor do bem-estar animal. Este artigo apresenta uma revisao sobre as caracteristicas estruturais e funcionais da IgY, bem como os metodos de producao, vantagens e aplicacoes em imunodiagnostico, alem das vantagens da sua utilizacao. Palavras-chave: anticorpo da gema do ovo, imunodiagnostico, imunoglobulina Y, anticorpo policlonal.
ISSN:0103-8478