Cyr61 expression in normal and neoplastic mammary glands of bitches/ Expressao de Cyr61 em glandulas mamarias normais e neoplasicas de cadelas

Mammary glands are the most usual sites of tumors in bitches, representing 25 to 30% of all types of cancer. During cancer genesis, several genetic changes alter the expression of different proteins like Cyr61, a peptide involved in cell proliferation and angiogenesis. This work aimed to determine t...

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Bibliographic Details
Published in:Ciência rural 2010-06, Vol.40 (6), p.1366
Main Authors: Miguel, Marina Pacheco, Sales, Tatyane Penha, de Menezes, Liliana Borges, Moraes, Julia Miranda, de Moura, Veridiana Maria Brianezi Dignani, Brito, Luiz Augusto Batista, de Araujo, Eugenio Goncalves
Format: Article
Language:Spanish
Subjects:
Analysis
Immunohistochemistry
Proteins
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Summary:Mammary glands are the most usual sites of tumors in bitches, representing 25 to 30% of all types of cancer. During cancer genesis, several genetic changes alter the expression of different proteins like Cyr61, a peptide involved in cell proliferation and angiogenesis. This work aimed to determine through immunohistochemistry the expression profile of Cyr61 in normal and neoplastic mammary glands from bitches. So, 10 cases of each diagnose were selected: simple adenoma, complex carcinoma, simple solid carcinoma and fragments of normal mammary glands, in a total of 40 cases. Sections were subjected to immunohistochemistry, employing primary antibodies directed Cyr61. Cyr61 labeling of normal mammary epithelial cells is probably linked to its role in apoptosis and cellular proliferation. The labeling was more intense in normal and adenoma fragments and was discrete in the labeling malignant tumor sections, a different feature of expression from previously reports in human breast cancer. Immunohistochemical analysis with polyclonal antibody Cyr61 demonstrated the constitutive expression of the protein and contributed to neoplastic research alternative for tumors in bitches.
ISSN:0103-8478