Use of the anabolic steroid nandrolone decanoate associated to strength training in Wistar rats/Uso do esteroide anabolico decanoato de nandrolona associado ao treinamento de forca em ratos Wistar

• Published in: Acta scientiarum. Biological sciences 2013-04, Vol.35 (2), p.283
• Main Authors: Andreato, Leonardo Vidal, Esteves, Joao Victor Del Conti, Almeida, Felipe Natali, Ribeiro, Tatiane Aparecida da Silva, Barrena, Helenton Cristhian, Peres, Sidney Barnabe, de Moraes, Solange Marta Franzoi
• Format: Article
• Language: Spanish
• Subjects: Anabolic steroids; Androgens; Aspartate; Body weight; Drugs and athletes; Physiological aspects; Weight training
• ISSN: 1679-9283
• DOI: 10.4025/actascibiolsci.v35i2.15513

Anabolic steroids have been constantly used among athletes and physically active individuals. Adverse effects of such use are reported in the literature. However, little is known about the effects of anabolic steroid use associated with strength training. Thus, this research aimed to identify possible morphophysiological alterations in Wistar rats treated with the anabolic steroid nandrolone decanoate and submitted to strength training. Twenty Wistar rats were divided in four groups: sedentary control (SC), sedentary hormone (SH), trained control (TC) and trained hormone (TH). After the experimental protocol period, animals were killed and body weight, adiposity, renal and hepatic injury markers, plasmatic lipid profile, glycemia, and insulinemia were determined. The experimental conditions strength training and nandrolone decanoate (isolated or associated) were positively correlated to a reduction on visceral and subcutaneous adipose tissue. The association of strength training with nandrolone decanoate was the most effective condition to increase muscle mass. Heart and kidneys weights, aspartate aminotransferase (AST) and high density lipoprotein (HDL) concentration were also negatively modified. The data demonstrated effects of anabolic steroids in body composition, with better results when associated with strength training, but collateral effects were observed. Keywords: anabolic steroids, nandrolone decanoate, strength training. Os esteroides anabolicos sao usados indiscriminadamente entre atletas e praticantes de atividades fisicas sendo que os efeitos adversos desse uso constam na literatura. Contudo, pouco se sabe dos efeitos do uso de esteroides anabolicos associados ao treinamento de forca. Assim, este estudo objetivou identificar possiveis alteracoes morfofisiologicas em ratos Wistar tratados com decanoato de nandrolona e submetidos ao treinamento de forca. Para atingir tal proposito, vinte ratos Wistar foram divididos em quatro grupos: sedentario controle (SC), sedentario hormonio (SH), treinado controle (TC) e treinado hormonio (TH). Apos o periodo experimental, foram analisados o peso corporal, a adiposidade, marcadores de lesoes hepaticas e renais, o perfil lipidico, a glicemia e a insulinemia. Foram observados efeitos do treinamento de forca e do uso de decanoato de nandrolona (isolados ou associados) nos tecidos adiposos viscerais e subcutaneo. A associacao de treinamento de forca e uso de decanoato de nandrolona foi mais efetiva para aume