Synthesis and Antimicrobial Activity of Thietanylpyrimidin-2,4(1H,3H)-Dione Acetanilides and Acetylhydrazones

Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1 H ,3 H )-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2 H )acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-ac...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-12, Vol.49 (9), p.598-601
Main Authors: Meshcheryakova, S. A., Kataev, V. A., Fattakhova, I. Ya, Nikolaeva, K. V., Bulgakov, A. K.
Format: Article
Language:English
Subjects:
Acetanilides
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1 H ,3 H )-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2 H )acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-acetylhydrazones. The antimicrobial and antifungal activities of the compounds synthesized here were studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1336-3