Synthesis and Antibacterial Activity of 1-[2-(4-Aminosulfonylphenyl)Ethyl]-5-Aryl-4-Aroyl-3-Hydroxy-3-Pyrrolin-2-Ones

Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy- 3-pyrrolin-2-ones. The structures of these compounds were verified by IR and 1 H NMR sp...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-12, Vol.49 (9), p.602-604
Main Authors: Gein, V. L., Bobrovskaya, O. V., Valiev, R. T., Odegova, T. F., Gartman, G. A.
Format: Article
Language:English
Subjects:
Antibacterial agents
Medicine
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy- 3-pyrrolin-2-ones. The structures of these compounds were verified by IR and 1 H NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1337-2