Investigation of therapeutic efficiency of phenytoin labeled with radioactive .sup.131I in the cancer cell lines

The aim of this study is to determine the incorporations of PHT radiolabeled with .sup.131I (.sup.131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of .sup.131I-PHT was obtained about 95 %. Subsequently, cel...

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Published in:Journal of radioanalytical and nuclear chemistry 2016-01, Vol.307 (1), p.131
Main Authors: Uzaras, Cansu, Avcibasi, Ugur, Demiroglu, Hasan, Medine, Emin Ilker, Kilcar, Ayfer Yurt, Muftuler, Fazilet Zumrut Biber, Unak, Perihan
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Language:English
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Cancer
Health aspects
Measurement
Phenytoin
Radiation
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container_title Journal of radioanalytical and nuclear chemistry
container_volume 307
creator Uzaras, Cansu
Avcibasi, Ugur
Demiroglu, Hasan
Medine, Emin Ilker
Kilcar, Ayfer Yurt
Muftuler, Fazilet Zumrut Biber
Unak, Perihan
description The aim of this study is to determine the incorporations of PHT radiolabeled with .sup.131I (.sup.131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of .sup.131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of .sup.131I, .sup.131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of .sup.131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, .sup.131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.
doi_str_mv 10.1007/s10967-015-4119-0
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subjects Cancer
Health aspects
Measurement
Phenytoin
Radiation
title Investigation of therapeutic efficiency of phenytoin labeled with radioactive .sup.131I in the cancer cell lines
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