Precision Medicine for Molecularly Targeted Agents and Immunotherapies in Early-Phase Clinical Trials

Precision medicine in oncology promises the matching of genomic, molecular, and clinical data with underlying mechanisms of a range of novel anticancer therapeutics to develop more rational and effective antitumor strategies in a timely manner. However, despite the remarkable progress made in the un...

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Bibliographic Details
Published in:Translational oncogenomics 2015-11, Vol.7 (Suppl 1), p.1
Main Authors: Lopez, Juanita, Harris, Sam, Roda, Desam, Yap, Timothy A
Format: Article
Language:English
Subjects:
Cancer
Care and treatment
Medical research
Medicine, Experimental
Methods
Molecular targeted therapy
Online Access:Get full text
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Summary:Precision medicine in oncology promises the matching of genomic, molecular, and clinical data with underlying mechanisms of a range of novel anticancer therapeutics to develop more rational and effective antitumor strategies in a timely manner. However, despite the remarkable progress made in the understanding of novel drivers of different oncogenic processes, success rates for the approval of oncology drugs remain low with substantial fiscal consequences. In this article, we focus on how recent rapid innovations in technology have brought greater clarity to the biological and clinical complexities of different cancers and advanced the development of molecularly targeted agents and immunotherapies in clinical trials. We discuss the key challenges of identifying and validating predictive biomarkers of response and resistance using both tumor and surrogate tissues, as well as the hurdles associated with intratumor heterogeneity. Finally, we outline evolving strategies employed in early-phase trial designs that incorporate omics-based technologies.
ISSN:1177-2727
1177-2727
DOI:10.4137/TOG.S30533.