Antidiabetic and Antilipidemic Effects of Some Polar and Nonpolar Extracts of Securigera Securidaca Flowers

Medicinal plants are widely used for pharmacological agents. These herbs are very rich sources of bioactive compounds. Securigera securidaca is reputed in folk medicine as antidiabetic and antilipidemic drug. In this research, the effect of solvent’s polarity in bioactive extract of this plant was e...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-02, Vol.49 (11), p.753-759
Main Authors: Ahmadi, Abbas, Khalili, Mohsen, Margedari, Shideh, Nahri-Niknafs, Babak
Format: Article
Language:English
Subjects:
Carbon tetrachloride
Dextrose
Fatty acids
Glucose
Medicinal Plants
Medicine
Medicine, Botanic
Medicine, Herbal
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Sterols
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Summary:Medicinal plants are widely used for pharmacological agents. These herbs are very rich sources of bioactive compounds. Securigera securidaca is reputed in folk medicine as antidiabetic and antilipidemic drug. In this research, the effect of solvent’s polarity in bioactive extract of this plant was evaluated by GC/MS analysis. Then, hypoglycemic and hypolipidemic activities of different extracts were studied in diabetic rats and compared to glibenclamide.The results showed that carbon tetrachloride extract of this plant has the best and significant activity for reducing of glucose and lipid levels compared to other extracts because of higher content of sterols and fatty acids.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1365-6