Haematological indices and bone marrow morphology in pancytopenia/bicytopenia

• Published in: The Egyptian journal of haematology : the official journal of the Egyptian Society of Haematology 2016-01, Vol.41 (1), p.23-26
• Main Authors: Dagdia, Kirti, Deshmukh, Anil, Soni, Ramawatar, Jane, Dilip
• Format: Article
• Language: English
• Subjects: Bone marrow; Care and treatment; Complications and side effects; Development and progression; Pancytopenia; Patient outcomes
• ISSN: 1110-1067; 2090-9268
• DOI: 10.4103/1110-1067.178476

Introduction Pancytopenia is an important clinicohaematological entity encountered in our day-to-day clinical practice. The possible underlying aetiologies range from transient viral marrow suppression to left-threatening malignant neoplasm. The aetiological diagnosis is essential for the clinical management and prognosis of the patient. Materials and methods In this study, a total of 75 cases of pancytopenia/bicytopenia were studied. Complete evaluation of clinical findings, haematological indices and bone marrow examination was carried out. Results Megaloblastic anaemia (29.3%) was the most common cause of pancytopenia/bicytopenia, followed by hypoplastic/aplastic anaemia (18.6%) and leukaemia (17.3%). Macrocytic anaemia was the predominant finding observed when studying peripheral smears, and a few cases of normocytic or microcytic anaemia were observed. Hypercellular marrow was seen in 68% of cases, whereas hypocellular marrow was present in 21.3% of cases. Conclusion Haematological indices and bone aspiration complemented with trephine biopsy is a useful, simple, economical and safe diagnostic tool in the evaluation of pancytopenia/bicytopenia. Egyptian J Haematol 41:-0 ͹ 2016 The Egyptian Society of Haematology.