Terminalia ferdinandiana extracts as inhibitors of Giardia duodenalis proliferation: a new treatment for giardiasis

Giardisis is a debilitating disease caused by gastrointestinal parasites of the genus Giardia. High-antioxidant T. ferdinandiana fruit extracts were investigated for the ability to block Giardia duodenalis growth. Methanolic and aqueous extracts had the most potent growth inhibitory activity (IC50 v...

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Bibliographic Details
Published in:Parasitology research (1987) 2015-07, Vol.114 (7), p.2611-2620
Main Authors: Rayan, P., Matthews, B., McDonnell, P. A., Cock, I. E.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Artemia - drug effects
Artemia - growth & development
Biomedical and Life Sciences
Biomedicine
Care and treatment
Fruit - chemistry
Giardia lamblia - drug effects
Giardia lamblia - growth & development
Giardiasis
Giardiasis - drug therapy
Health aspects
Host-bacteria relationships
Immunology
Medical Microbiology
Microbiology
Original Paper
Plant extracts
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Prevention
Rosidae
Terminalia - chemistry
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Summary:Giardisis is a debilitating disease caused by gastrointestinal parasites of the genus Giardia. High-antioxidant T. ferdinandiana fruit extracts were investigated for the ability to block Giardia duodenalis growth. Methanolic and aqueous extracts had the most potent growth inhibitory activity (IC50 values of approximately 700 and 140 μg/ml, respectively). Ethyl acetate and chloroform extracts also inhibited G. duodenalis growth, albeit with lower potency. The hexane extract was completely devoid of G. duodenalis growth inhibitory activity. All extracts were nontoxic in the Artemia fransiscana bioassay. Nontargeted HPLC-quadrupole time-of-flight (QTOF) mass spectroscopy (with screening against three compound databases) putatively identified 17 compounds in all of the inhibitory extracts but not in the inactive hexane extract. The low toxicity of the Terminalia ferdinandiana fruit extracts and their potent G. duodenalis growth inhibitory bioactivity indicate their potential as medicinal agents in the treatment and prevention of this disease.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-015-4465-4