Synthesis and Antibacterial Activity of 3,4-Diaryl-5-(4-Guanidylsulfonylphenyl)-4,6-Dihydropyrrolo[3, 4-C]Pyrazol-6-Ones

Interaction of 1,4,5-trisubstituted tetrahydropyrrol-2,3-diones with hydrazine hydrate was used to synthesize 3,4-diaryl5-(4-guanidylsulfonylphenyl)-4,6-dihydropyrrolo[3,4- c ]pyrazol-6-ones. The antibacterial activity of these compounds was investigated.

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-04, Vol.50 (1), p.16-18
Main Authors: Bobrovskaya, O. V., Kovtonogova, I. V., Gein, V. L., Gein, L. F., Odegova, T. F.
Format: Article
Language:English
Subjects:
Antibacterial agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Resveratrol
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Summary:Interaction of 1,4,5-trisubstituted tetrahydropyrrol-2,3-diones with hydrazine hydrate was used to synthesize 3,4-diaryl5-(4-guanidylsulfonylphenyl)-4,6-dihydropyrrolo[3,4- c ]pyrazol-6-ones. The antibacterial activity of these compounds was investigated.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1390-5