Discovery of a novel human pegivirus in blood associated with hepatitis c virus coinfection

Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Fiaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generat...

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Bibliographic Details
Published in:PLoS pathogens 2015-12
Main Authors: Berg, Michael G, Lee, Deanna, Coller, Kelly, Frankel, Matthew, Aronsohn, Andrew, Cheng, Kevin, Forberg, Kenn, Marcinkus, Marilee, Naccache, Samia N, Dawson, George, Brennan, Catherine, Jensen, Donald M, Hackett, Jr., John, Chiu, Charles Y
Format: Article
Language:English
Subjects:
Comorbidity
Development and progression
Discovery and exploration
Hepatitis C virus
RNA viruses
Virus diseases
Virus research
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Summary:Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Fiaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of plasma from an HCV-infected patient with multiple bloodborne exposures who died from sepsis of unknown etiology. HPgV-2 is highly divergent, situated on a deep phylogenetic branch in a clade that includes rodent and bat pegiviruses, with which it shares
ISSN:1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005325