Peculiarities of the inflammatory process in the reproductive organs of C57B1/6 female mice with experimental tuberculosis

• Published in: Bulletin of experimental biology and medicine 2016-04, Vol.160 (6), p.787
• Main Authors: Sukhikh, G.T, Kayukova, S.I, Bocharova, I.V, Donnikov, A.E, Lepekha, L.N, Demikhova, O.V, Uvarova, E.V, Berezovskii, Yu. S, Smirnova, T.G
• Format: Article
• Language: English
• Subjects: Antitubercular agents; Inflammation; Microbiota (Symbiotic organisms); Tuberculosis
• ISSN: 0007-4888
• DOI: 10.1007/s10517-016-3310-9

Intravenous infection of C57B1/6 female mice with M. tuberculosis H37Rv led to involvement of the lungs and dissemination of the tuberculous infection to the abdominal and pelvic organs. M. tuberculosis were detected in the lungs and spleen in 14, 35, and 90 days and in the uterine horns in 90 days after infection. Morphological analysis of organs showed successive development of exudative necrotic tuberculosis of the lungs, acute and chronic nonspecific inflammation in the reproductive organs (vagina, uterus, and uterine horns). The inflammatory process in the reproductive organs was associated with the development of anaerobic dysbiosis, that was most pronounced in 35 days after infection. Antituberculous therapy was followed by reduction of M. tuberculosis count in the lungs and spleen in 60 and 90 days after infection, eliminatation of M. tuberculosis in the uterine horns, arrest of nonspecific inflammation in female reproductive organs, recovery of the balance between aerobic and anaerobic microflora, and development of candidiasis of the urogenital mucosa. Key Words: experimental tuberculosis; inbred mice; inflammation; reproductive organs