Brown adipose tissue and bone

Brown adipose tissue (BAT) is capable of transforming chemically stored energy, in the form of triglycerides, into heat. Recent studies have shown that metabolically active BAT is present in a large proportion of adult humans, where its activity correlates with a favorable metabolic status. Hence, t...

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Bibliographic Details
Published in:International Journal of Obesity 2015-08, Vol.5 (Suppl 1), p.S23-S27
Main Authors: Lidell, M E, Enerbäck, S
Format: Article
Language:English
Subjects:
631/443/319
692/4023/1671
692/698/690/2816
692/699/2743/393
Body fat
Bone density
Bones
Brown adipose tissue
Epidemiology
Health Promotion and Disease Prevention
Internal Medicine
Medicine & Public Health
Metabolic Diseases
Physiological aspects
Public Health
Review
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Summary:Brown adipose tissue (BAT) is capable of transforming chemically stored energy, in the form of triglycerides, into heat. Recent studies have shown that metabolically active BAT is present in a large proportion of adult humans, where its activity correlates with a favorable metabolic status. Hence, the tissue is now regarded as an interesting target for therapies against obesity and associated diseases such as type 2 diabetes, the hypothesis being that an induction of BAT would be beneficial for these disease states. Apart from the association between BAT activity and a healthier metabolic status, later studies have also shown a positive correlation between BAT volume and both bone cross-sectional area and bone mineral density, suggesting that BAT might stimulate bone anabolism. The aim of this review is to give the reader a brief overview of the BAT research field and to summarize and discuss recent findings regarding BAT being a potential player in bone metabolism.
ISSN:2046-2166
0307-0565
2046-2174
DOI:10.1038/ijosup.2015.7