Central Sleep Apnoea Is Related to the Severity and Short-Term Prognosis of Acute Coronary Syndrome

To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Observational study with cross-sectional and longitudinal analyses. Patients acutely admitted to participating hospitals because of ACS underwent...

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Published in:PLoS ONE 2016, Vol.11 (11), p.e0167031
Main Authors: Florés, Marina, de Batlle, Jordi, Sánchez-de-la-Torre, Alicia, Sánchez-de-la-Torre, Manuel, Aldomá, Albina, Worner, Fernando, Galera, Estefanía, Seminario, Asunción, Torres, Gerard, Dalmases, Mireia, Montserrat, Josep M, Garmendia, Onintza, Barbé, Ferran
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Language:English
Subjects:
Acute coronary syndrome
Complications and side effects
Diagnosis
Prognosis
Risk factors
Sleep apnea
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container_issue 11
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container_title PLoS ONE
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creator Florés, Marina
de Batlle, Jordi
Sánchez-de-la-Torre, Alicia
Sánchez-de-la-Torre, Manuel
Aldomá, Albina
Worner, Fernando
Galera, Estefanía
Seminario, Asunción
Torres, Gerard
Dalmases, Mireia
Montserrat, Josep M
Garmendia, Onintza
Barbé, Ferran
description To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Observational study with cross-sectional and longitudinal analyses. Patients acutely admitted to participating hospitals because of ACS underwent respiratory polygraphy during the first 24 to 72 h. CSA was defined as an apnoea-hypopnoea index (AHI) >15 events*h.sup.-1 (>50% of central apnoeas). ACS severity (Killip class, ejection fraction, number of diseased vessels and peak plasma troponin) was evaluated at baseline, and short-term prognosis (length of hospitalization, complications and mortality) was evaluated at discharge. A total of 68 CSA patients (AHI 31±18 events*h.sup.-1, 64±12 years, 87% males) and 92 controls (AHI 7±5 events*h.sup.-1, 62±12 years, 84% males) were included in the analyses. After adjusting for age, body mass index, hypertension and smoking status, patients diagnosed with CSA spent more days in the coronary unit compared with controls (3.7±2.9 vs. 1.5±1.7; p
doi_str_mv 10.1371/journal.pone.0167031
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Observational study with cross-sectional and longitudinal analyses. Patients acutely admitted to participating hospitals because of ACS underwent respiratory polygraphy during the first 24 to 72 h. CSA was defined as an apnoea-hypopnoea index (AHI) &gt;15 events*h.sup.-1 (&gt;50% of central apnoeas). ACS severity (Killip class, ejection fraction, number of diseased vessels and peak plasma troponin) was evaluated at baseline, and short-term prognosis (length of hospitalization, complications and mortality) was evaluated at discharge. A total of 68 CSA patients (AHI 31±18 events*h.sup.-1, 64±12 years, 87% males) and 92 controls (AHI 7±5 events*h.sup.-1, 62±12 years, 84% males) were included in the analyses. After adjusting for age, body mass index, hypertension and smoking status, patients diagnosed with CSA spent more days in the coronary unit compared with controls (3.7±2.9 vs. 1.5±1.7; p&lt;0.001) and had a worse Killip class (Killip I: 16% vs. 96%; p&lt;0.001). No differences were observed in ejection fraction estimates. CSA patients exhibited increased ACS severity as indicated by their Killip classification. These patients had a worse prognosis, with longer lengths of stay in the coronary care units. 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subjects Acute coronary syndrome
Complications and side effects
Diagnosis
Prognosis
Risk factors
Sleep apnea
title Central Sleep Apnoea Is Related to the Severity and Short-Term Prognosis of Acute Coronary Syndrome
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