Plasma Levels of Inter-[alpha] Inhibitor Proteins in Children with Acute Dengue Virus Infection

Inter-[alpha] inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp...

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Bibliographic Details
Published in:PloS one 2010-04, Vol.5 (4), p.e9967
Main Authors: Koraka, Penelope, Lim, Yow-Pin, Shin, Michael D, Setiati, Tatty E, Mairuhu, Albert T. A, van Gorp, Eric C. M, Soemantri, Augustinus, Osterhaus, Albert D. M. E, Martina, Byron E. E
Format: Article
Language:English
Subjects:
Child health
Dengue virus
Infection
Medical research
Pediatrics
Permeability
Protease inhibitors
Proteases
Proteins
Virus diseases
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Summary:Inter-[alpha] inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker. Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls. This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0009967