Albumin and surgical site infection risk in orthopaedics: a meta-analysis

• Published in: BMC Surgery 2017, Vol.17 (1)
• Main Authors: Yuwen, Peizhi, Chen, Wei, Lv, Hongzhi, Feng, Chen, Li, Yansen, Zhang, Tao, Hu, Pan, Guo, Jialiang, Tian, Ye, Liu, Lei, Sun, Jiayuan, Zhang, Yingze
• Format: Report
• Language: English
• Subjects: Albumin; Health aspects; Postoperative complications; Risk factors
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-016-0186-6

Backgroud A basic data search was performed in PubMed and Web of Science, in addition, references were manually searched. All of the observational studies contained preoperative albumin, outcomes of SSI or valuable data that could be abstracted and analysed for meta-analysis in orthopaedics. All of the studies were assessed using the classic Newcastle Ottawa Scale (NOS). They conformed to critical quality evaluation standards, and the final data analysis was performed with RevMan 5.2 software. A total of 112,183 patients included in 13 studies were involved. The pooled MD of albumin between the infection group and the non-infection group was MD = -2.28 (95 % CI -3.97-0.58), which was statistically significant (z = 2.63, P = 0.008). The pooled RR of infection when comparing albumin 3.5 was 2.39 (95 % CI 1.57 3.64), which was statistically significant (z = 4.06, P < 0.0001). Heterogeneity were found in the pooled MD of albumin and in the pooled RR for infection (P = 0.05, I.sup.2 = 61 % and P = 0.003, I.sup.2 = 68 %). No publication bias occurred based on two basically symmetrical funnel plots. Our meta-analysis demonstrated that an albumin level