Ataxia-Telangiectasia Group D Complementing Gene Promotes Lung Cancer Cell Proliferation by Activating NF-[kappa]B Pathway

Previous studies suggested Ataxia-telangiectasia group D complementing gene (ATDC) as an oncogene in many types of cancer. However, its expression and biological functions in non-small cell lung cancer (NSCLC) remain unclear. Herein, we investigated its expression pattern in 109 cases of human NSCLC...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e63676
Main Authors: Tang, Zhong-Ping, Dong, Qian-Ze, Cui, Quan-Zhe, Papavassiliou, Paulie, Wang, En-Di, Wang, En-Hua
Format: Article
Language:English
Subjects:
Analysis
Ataxia
Ataxia telangiectasia
Cancer genetics
Genes
Genetic aspects
Immunohistochemistry
Luciferase
Non-small cell lung cancer
Tumor proteins
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Summary:Previous studies suggested Ataxia-telangiectasia group D complementing gene (ATDC) as an oncogene in many types of cancer. However, its expression and biological functions in non-small cell lung cancer (NSCLC) remain unclear. Herein, we investigated its expression pattern in 109 cases of human NSCLC samples by immunohistochemistry and found that ATDC was overexpressed in 62 of 109 NSCLC samples (56.88%). ATDC overexpression correlated with histological type (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063676