Mucosal Tolerance to a Combination of ApoB and HSP60 Peptides Controls Plaque Progression and Stabilizes Vulnerable Plaque in Apob.sup.tm2SgyLdlr.sup.tm1Her/J Mice

Oral tolerance to auto antigens reduces the development of atherosclerosis in mouse models. However, the effect of immune tolerance to multiple self antigenic peptides in plaque progression and stabilization is not known. We studied the protective effect of mucosal tolerance to peptides from apolipo...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e58364
Main Authors: Mundkur, Lakshmi, Mukhopadhyay, Rupak, Samson, Sonia, Varma, Meenakshi, Kale, Dnyaneswar, Chen, Daxin, Shivaprasad, Sneha, Sivanandan, Hemapriya, Soman, Vinod, Lu, Xinjie, Kakkar, Vijay V
Format: Article
Language:English
Subjects:
Analysis
Antigens
Atherosclerosis
Bone morphogenetic proteins
Heat shock proteins
Hypercholesterolemia
Peptides
T cells
Transforming growth factors
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Summary:Oral tolerance to auto antigens reduces the development of atherosclerosis in mouse models. However, the effect of immune tolerance to multiple self antigenic peptides in plaque progression and stabilization is not known. We studied the protective effect of mucosal tolerance to peptides from apolipoprotein B (ApoB; 661-680) and heat shock protein 60 (HSP60; 153-163), in combination with diet, in the prevention of atherosclerotic lesion progression and plaque stabilization in ApoB.sup.tm25gy LDLr.sup.tm1Her mice. We found that oral administration of five doses of a combination of ApoB and HSP60 peptides (20 [micro]g/mice/dose) induced tolerance to both the peptides and reduced early plaque development by 39.9% better than the individual peptides (ApoB = 28.7%;HSP60 = 26.8%)(P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0058364