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Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids
Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthet...
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Published in: | Pharmaceutical chemistry journal 2017, Vol.50 (10), p.649-653 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity. |
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ISSN: | 0091-150X 1573-9031 |
DOI: | 10.1007/s11094-017-1507-5 |