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Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids

Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthet...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2017, Vol.50 (10), p.649-653
Main Authors: Zimin, Yu. S., Borisova, N. S., Timerbaeva, G. R., Gimadieva, A. R., Mustafin, A. G.
Format: Article
Language:English
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Summary:Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-017-1507-5