Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography–mass spectrometry

A method is developed for the determination of steroid hormones in urine using gas chromatography with mass-spectrometric detection. Sample preparation procedure and the conditions of chromatographic analysis were optimized, and characteristic urinary steroid profiles of patients with adrenocortical...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-07, Vol.71 (7), p.748-754
Main Authors: Velikanova, L. I., Strel’nikova, E. G., Obedkova, E. V., Krivokhizhina, N. S., Shafigullina, Z. R., Grigoryan, K., Povarov, V. G., Moskvin, A. L.
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Chemical properties
Chemistry
Chemistry and Materials Science
Gas chromatography
Mass spectrometry
Steroids (Organic compounds)
Urinalysis
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Summary:A method is developed for the determination of steroid hormones in urine using gas chromatography with mass-spectrometric detection. Sample preparation procedure and the conditions of chromatographic analysis were optimized, and characteristic urinary steroid profiles of patients with adrenocortical cancer were obtained. Criteria for the evaluation of the deficiency of 21-hydroxylase and 11β-hydroxylase in patients with adrenal incidentaloma are proposed.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934816070169