Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch

The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute infla...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.730
Main Authors: Chelombitko, M.A, Averina, O.A, Vasileva, T.V, Dvorianinova, E.E, Egorov, M.V, Pletjushkina, O.Yu, Popova, E.N, Fedorov, A.V, Romashchenko, V.P, Ilyinskaya, O.P
Format: Article
Language:English
Subjects:
Antioxidants (Nutrients)
Bromine compounds
Carrageenan
Cytokines
Inflammation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 6
container_start_page 730
container_title Bulletin of experimental biology and medicine
container_volume 162
creator Chelombitko, M.A
Averina, O.A
Vasileva, T.V
Dvorianinova, E.E
Egorov, M.V
Pletjushkina, O.Yu
Popova, E.N
Fedorov, A.V
Romashchenko, V.P
Ilyinskaya, O.P
description The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process. Key Words: mitochondria-targeted antioxidants; SkQ1; C12TPP; acute inflammation; carrageenan
doi_str_mv 10.1007/s10517-017-3699-9
format article
fullrecord <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A498583290</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A498583290</galeid><sourcerecordid>A498583290</sourcerecordid><originalsourceid>FETCH-LOGICAL-g670-b14df3a3759a4e5ff793a8d336bead3394f22ae712cbeda504becfc8b259af233</originalsourceid><addsrcrecordid>eNptTstqwzAQ9KGFpo8P6E3Qs1LZsmP7GEJfEOgl97CWVraKJQVLhuYv-0ld0x56KGI1zGhmR1l2n4t1LkT9GHNR5TUXNHLTtry9yFaCHnjZNM1Vdh3jx0LFJl9lX7vgTjDZGDwLhqUBGRqDKsWFOpuCGoLXkwWeYOoxoWbgkw2fVhOyXHDipDEzQe-QJMpZirswoppHZDpoVOcxTfY0oD-PpyFEGm9nx6hVwURJRA-eW69ntTSoOSGz3ozgHFCbJ0Ib54h0axyXkjh3i80jyQzsxE5hVsNtdmlgjHj3izfZ4fnpsHvl-_eXt912z_tNLXiXl9pIkHXVQomVMXUrodFSbjoEgrY0RQFY54XqUEMlyg6VUU1XUMAUUt5kDz9rexjxSD8NaQLlbFTHbdk2VSOLVpBr_Y-LjkZnVfBoLOl_At-V-pDI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch</title><source>Springer Nature</source><creator>Chelombitko, M.A ; Averina, O.A ; Vasileva, T.V ; Dvorianinova, E.E ; Egorov, M.V ; Pletjushkina, O.Yu ; Popova, E.N ; Fedorov, A.V ; Romashchenko, V.P ; Ilyinskaya, O.P</creator><creatorcontrib>Chelombitko, M.A ; Averina, O.A ; Vasileva, T.V ; Dvorianinova, E.E ; Egorov, M.V ; Pletjushkina, O.Yu ; Popova, E.N ; Fedorov, A.V ; Romashchenko, V.P ; Ilyinskaya, O.P</creatorcontrib><description>The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process. Key Words: mitochondria-targeted antioxidants; SkQ1; C12TPP; acute inflammation; carrageenan</description><identifier>ISSN: 0007-4888</identifier><identifier>DOI: 10.1007/s10517-017-3699-9</identifier><language>eng</language><publisher>Springer</publisher><subject>Antioxidants (Nutrients) ; Bromine compounds ; Carrageenan ; Cytokines ; Inflammation</subject><ispartof>Bulletin of experimental biology and medicine, 2017-04, Vol.162 (6), p.730</ispartof><rights>COPYRIGHT 2017 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Chelombitko, M.A</creatorcontrib><creatorcontrib>Averina, O.A</creatorcontrib><creatorcontrib>Vasileva, T.V</creatorcontrib><creatorcontrib>Dvorianinova, E.E</creatorcontrib><creatorcontrib>Egorov, M.V</creatorcontrib><creatorcontrib>Pletjushkina, O.Yu</creatorcontrib><creatorcontrib>Popova, E.N</creatorcontrib><creatorcontrib>Fedorov, A.V</creatorcontrib><creatorcontrib>Romashchenko, V.P</creatorcontrib><creatorcontrib>Ilyinskaya, O.P</creatorcontrib><title>Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch</title><title>Bulletin of experimental biology and medicine</title><description>The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process. Key Words: mitochondria-targeted antioxidants; SkQ1; C12TPP; acute inflammation; carrageenan</description><subject>Antioxidants (Nutrients)</subject><subject>Bromine compounds</subject><subject>Carrageenan</subject><subject>Cytokines</subject><subject>Inflammation</subject><issn>0007-4888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptTstqwzAQ9KGFpo8P6E3Qs1LZsmP7GEJfEOgl97CWVraKJQVLhuYv-0ld0x56KGI1zGhmR1l2n4t1LkT9GHNR5TUXNHLTtry9yFaCHnjZNM1Vdh3jx0LFJl9lX7vgTjDZGDwLhqUBGRqDKsWFOpuCGoLXkwWeYOoxoWbgkw2fVhOyXHDipDEzQe-QJMpZirswoppHZDpoVOcxTfY0oD-PpyFEGm9nx6hVwURJRA-eW69ntTSoOSGz3ozgHFCbJ0Ib54h0axyXkjh3i80jyQzsxE5hVsNtdmlgjHj3izfZ4fnpsHvl-_eXt912z_tNLXiXl9pIkHXVQomVMXUrodFSbjoEgrY0RQFY54XqUEMlyg6VUU1XUMAUUt5kDz9rexjxSD8NaQLlbFTHbdk2VSOLVpBr_Y-LjkZnVfBoLOl_At-V-pDI</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Chelombitko, M.A</creator><creator>Averina, O.A</creator><creator>Vasileva, T.V</creator><creator>Dvorianinova, E.E</creator><creator>Egorov, M.V</creator><creator>Pletjushkina, O.Yu</creator><creator>Popova, E.N</creator><creator>Fedorov, A.V</creator><creator>Romashchenko, V.P</creator><creator>Ilyinskaya, O.P</creator><general>Springer</general><scope/></search><sort><creationdate>20170401</creationdate><title>Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch</title><author>Chelombitko, M.A ; Averina, O.A ; Vasileva, T.V ; Dvorianinova, E.E ; Egorov, M.V ; Pletjushkina, O.Yu ; Popova, E.N ; Fedorov, A.V ; Romashchenko, V.P ; Ilyinskaya, O.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g670-b14df3a3759a4e5ff793a8d336bead3394f22ae712cbeda504becfc8b259af233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antioxidants (Nutrients)</topic><topic>Bromine compounds</topic><topic>Carrageenan</topic><topic>Cytokines</topic><topic>Inflammation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chelombitko, M.A</creatorcontrib><creatorcontrib>Averina, O.A</creatorcontrib><creatorcontrib>Vasileva, T.V</creatorcontrib><creatorcontrib>Dvorianinova, E.E</creatorcontrib><creatorcontrib>Egorov, M.V</creatorcontrib><creatorcontrib>Pletjushkina, O.Yu</creatorcontrib><creatorcontrib>Popova, E.N</creatorcontrib><creatorcontrib>Fedorov, A.V</creatorcontrib><creatorcontrib>Romashchenko, V.P</creatorcontrib><creatorcontrib>Ilyinskaya, O.P</creatorcontrib><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chelombitko, M.A</au><au>Averina, O.A</au><au>Vasileva, T.V</au><au>Dvorianinova, E.E</au><au>Egorov, M.V</au><au>Pletjushkina, O.Yu</au><au>Popova, E.N</au><au>Fedorov, A.V</au><au>Romashchenko, V.P</au><au>Ilyinskaya, O.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><date>2017-04-01</date><risdate>2017</risdate><volume>162</volume><issue>6</issue><spage>730</spage><pages>730-</pages><issn>0007-4888</issn><abstract>The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process. Key Words: mitochondria-targeted antioxidants; SkQ1; C12TPP; acute inflammation; carrageenan</abstract><pub>Springer</pub><doi>10.1007/s10517-017-3699-9</doi></addata></record>
fulltext fulltext
identifier ISSN: 0007-4888
ispartof Bulletin of experimental biology and medicine, 2017-04, Vol.162 (6), p.730
issn 0007-4888
language eng
recordid cdi_gale_infotracmisc_A498583290
source Springer Nature
subjects Antioxidants (Nutrients)
Bromine compounds
Carrageenan
Cytokines
Inflammation
title Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T17%3A40%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20the%20effects%20of%20mitochondria-targeted%20antioxidant%2010-%20and%20a%20fragment%20of%20its%20molecule%20dodecyltriphenylphosphonium%20on%20carrageenan-induced%20acute%20inflammation%20in%20mouse%20model%20of%20subcuteneous%20air%20pouch&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Chelombitko,%20M.A&rft.date=2017-04-01&rft.volume=162&rft.issue=6&rft.spage=730&rft.pages=730-&rft.issn=0007-4888&rft_id=info:doi/10.1007/s10517-017-3699-9&rft_dat=%3Cgale%3EA498583290%3C/gale%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-g670-b14df3a3759a4e5ff793a8d336bead3394f22ae712cbeda504becfc8b259af233%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A498583290&rfr_iscdi=true