Selective blockade of [[alpha].sub.2]-Adrenoceptor subtypes modulates contractility of rat myocardium

The study examined the dose-dependent effects of selective antagonists of [[alpha].sub.2A/D]-, [[alpha].sub.2B]-, and [[alpha].sub.2C]adrenoceptors applied in concentrations of 10~9-10~5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each [[alpha].sub.2]-...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-12, Vol.162 (2), p.177
Main Authors: Zefirov, T.L, Khisamieva, L.I, Ziyatdinova, N.I, Zefirov, A.L
Format: Article
Language:English
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Summary:The study examined the dose-dependent effects of selective antagonists of [[alpha].sub.2A/D]-, [[alpha].sub.2B]-, and [[alpha].sub.2C]adrenoceptors applied in concentrations of 10~9-10~5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each [[alpha].sub.2]-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of [[alpha].sub.2A/D]- and [[alpha].sub.2C]adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. [[alpha].sub.2B]-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles. Key Words: heart; chronotropy; [[alpha].sub.2]-adrenoceptor; rat
ISSN:0007-4888
DOI:10.1007/s10517-016-3569-x