Synthesis and Antimicrobial Activity of Tricyclic Quinazolinethiones

Deoxyvasicine thione ( III ) and mackinazoline thione (6,7,8,9-tetrahydro-11 H -pyrido[2,1- b ]quinazoline-11-thione, IV ) were synthesized and condensed with aromatic and heterocyclic aldehydes at the α-methylene [CH 2 -3 ( III ) or CH 2 -6 ( IV )]. Either 3- and 6-arylidene derivatives ( V – XIII...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2017-08, Vol.51 (5), p.355-360
Main Authors: Nasrullaev, A. O., Islamova, Zh. I., Élmuradov, B. Zh, Bektemirov, A. M., Osipova, S. O., Khushbaktova, Z. A., Syrov, V. N., Shakhidoyatov, Kh. M.
Format: Article
Language:English
Subjects:
Epidemiology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Deoxyvasicine thione ( III ) and mackinazoline thione (6,7,8,9-tetrahydro-11 H -pyrido[2,1- b ]quinazoline-11-thione, IV ) were synthesized and condensed with aromatic and heterocyclic aldehydes at the α-methylene [CH 2 -3 ( III ) or CH 2 -6 ( IV )]. Either 3- and 6-arylidene derivatives ( V – XIII ) or 6-hydroxymethylaryl derivatives ( XIV ) were formed depending on the reaction conditions. Formylation of IV synthesized the 6-hydroxymethylidene derivative ( XV ). 6-Chloro-, -hydroseleno-, and -anilinomethylidenemackinazoline thiones ( XVI – XIX ) were also synthesized. The antimicrobial activity of the synthesized compounds against S. aureus , E. coli , Bacillus cereus , Candida albicans , and Pseudomonas aeruginosa was studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-017-1614-3