Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.02,6.08,10]Dodec-11-EN-4-YL)Ureas

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azate...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2017-09, Vol.51 (6), p.439-443
Main Authors: Selivanov, B. A., Tikhonov, A. Y., Belanov, E. F., Bormotov, N. I., Kabanov, A. S., Mazurkov, O. Yu, Serova, O. A., Shishkina, L. N., Agafonov, A. P., Sergeev, A. N.
Format: Article
Language:English
Subjects:
Antiviral agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-017-1629-9