Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/[beta]-catenin signaling

Aberrant activation of Wnt/[beta]-catenin signaling leads to increased cell proliferation and survival and promotes the development of various human tumors, including glioma, one of the most common primary brain tumors. The treatment efficacy of many anticancer drugs remains limited or unsatisfactor...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 2017-12, Vol.370 (3), p.379
Main Authors: Tao, Qingxia, Wu, Cuiying, Xu, Ruxiang, Niu, Lijun, Qin, Jiazhen, Liu, Ning, Zhang, Peng
Format: Article
Language:English
Subjects:
Brain tumors
Cancer treatment
Development and progression
Gliomas
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aberrant activation of Wnt/[beta]-catenin signaling leads to increased cell proliferation and survival and promotes the development of various human tumors, including glioma, one of the most common primary brain tumors. The treatment efficacy of many anticancer drugs remains limited or unsatisfactory and it is urgently necessary to develop effective and low-toxicity anticancer drugs or strategies, especially for glioma. Here, we report that diallyl trisulfide suppresses survival, migration, invasion and angiogenesis in glioma cells. These effects were associated with inhibition of the Wnt/[beta]-catenin signaling cascade, which was accompanied by decreased expression of LRP6, TRIM29 and Pygo2. A dual-luciferase reporter assay confirmed that DATS treatment decreased TCF/LEF-mediated transcription. Finally, a nude mouse tumorigenicity model was used to examine the biological effect of diallyl trisulfide in vivo. Consistent with the previous results, diallyl trisulfide inhibited proliferation, invasion and angiogenesis in glioma cells by suppressing Wnt/[beta]-catenin signaling.
ISSN:0302-766X
DOI:10.1007/s00441-017-2678-9