FOXP3.sup.+ T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome

Background Tubulointerstitial nephritis (TIN) is an inflammatory disease of unknown pathogenesis. To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and quantity of FOXP3.sup.+ T regulatory lymphocytes...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2018-02, Vol.33 (2), p.287
Main Authors: Rytkönen, Sari H, Kulmala, Petri, Autio-Harmainen, Helena, Arikoski, Pekka, Endén, Kira, Kataja, Janne, Karttunen, Tuomo
Format: Article
Language:English
Subjects:
Diagnosis
Forkhead transcription factors
Kidney biopsy
Nephritis
Pediatric respiratory diseases
Uveitis
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Summary:Background Tubulointerstitial nephritis (TIN) is an inflammatory disease of unknown pathogenesis. To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and quantity of FOXP3.sup.+ T regulatory lymphocytes in diagnostic kidney biopsies from pediatric patients. Methods A total of 33 patients (14 TIN and 19 TINU) were enrolled. The quantity of CD4.sup.+, FOXP3.sup.+ and double-positive T cells in formalin-fixed kidney biopsies was determined using double label immunohistochemistry with anti-human CD4 and FOXP3 antibodies. Results FOXP3 staining was successful in all 33 patients. In patients with chronic uveitis, the density of FOXP3.sup.+ cells was significantly lower (p = 0.046) than in TIN patients without uveitis or with uveitis lasting
ISSN:0931-041X
DOI:10.1007/s00467-017-3796-z