Experimental Antioxidant Activity of a [beta]-Cyclodextrin - Histochrome Complex

A2:1 [beta]-cyclodextrin - histochrome complex was synthesized based on a comparison with experimental studies of histochrome and showed antioxidant activity prolonged to 16 d as compared with 6 d for histochrome in tests of the duration of the in vitro antioxidant effect. PMR measurements proved th...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2018-02, Vol.51 (11), p.980
Main Authors: Bikbov, M. M, Nikitin, N. A, Surkova, V. K, Farkhutdinov, R. R, Khalilov, L. M, Tulyabaev, A. R, Nikitina, A. F
Format: Article
Language:English
Subjects:
Antioxidants (Nutrients)
Cyclodextrins
Online Access:Get full text
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Summary:A2:1 [beta]-cyclodextrin - histochrome complex was synthesized based on a comparison with experimental studies of histochrome and showed antioxidant activity prolonged to 16 d as compared with 6 d for histochrome in tests of the duration of the in vitro antioxidant effect. PMR measurements proved that a [beta]-cyclodextrin - histochrome complex formed. Computer modeling of the [beta]-cyclodextrin-histochrome complex showed that the head-to-tail complex corresponded to the energy minimum.
ISSN:0091-150X
DOI:10.1007/s11094-018-1727-3