Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting in day-case gynaecological laparoscopic surgeries

Background: Postoperative nausea and vomiting is a common complication following general anaesthesia for gynaecological laparoscopic procedures. Objective: This prospective study was designed to compare the efficacies of ondansetron and metoclopramide in the prevention of postoperative nausea and vo...

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Bibliographic Details
Published in:Nigerian journal of basic and clinical sciences 2018-01, Vol.15 (1), p.24-28
Main Authors: Dalhat, Salahu, Mohammad, Alhassan
Format: Article
Language:English
Subjects:
Complications and side effects
Dosage and administration
Laparoscopy
Metoclopramide
Nausea
Ondansetron
Postoperative complications
Prevention
Risk factors
Vomiting
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Summary:Background: Postoperative nausea and vomiting is a common complication following general anaesthesia for gynaecological laparoscopic procedures. Objective: This prospective study was designed to compare the efficacies of ondansetron and metoclopramide in the prevention of postoperative nausea and vomiting (PONV) after day-case gynaecological laparoscopic surgeries. Materials and Methods: Sixty-six ASA I and II consenting patients aged 18-55 years undergoing day-case gynaecological laparoscopic procedures were recruited and randomly allocated into two groups with each receiving either intravenous ondansetron 4 mg or intravenous metoclopramide 10 mg prior to the induction of anaesthesia. Nausea and vomiting were then assessed over a period of 4 hours before discharge. Results: Nausea occurred in 33.3% and 15.2% of the patients in the metoclopramide and ondansetron groups, respectively (P = 0.001). The incidence of vomiting was 9.1% and 3% (P < 0.0001) for metoclopramide and ondansetron, respectively. Conclusion: Ondansetron offered superior prophylaxis against PONV compared to metoclopramide in patients undergoing day-case gynaecological laparoscopic surgery.
ISSN:0331-8540
DOI:10.4103/njbcs.njbcs_15_17