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Paraneoplastic Neurologic Syndromes: Rare But More Common Than Expected Nine Cases with a Literature Review/Paraneoplastik Norolojik Sendromlar: Nadir Ancak Beklenenden Daha Sik Dokuz Olgu ile Literatur Derlemesi
Paraneoplastic neurologic syndromes (PNS) are rare disorders, which are remote effects of cancer that are not caused by the tumor, its metastasis or side effects of treatment. We had nine patients with PNS; two of our patients had limbic encephalitis, but one had autoimmune limbic encephalitis with...
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Published in: | Türk nöroloji dergisi 2018-03, Vol.24 (1), p.63 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Paraneoplastic neurologic syndromes (PNS) are rare disorders, which are remote effects of cancer that are not caused by the tumor, its metastasis or side effects of treatment. We had nine patients with PNS; two of our patients had limbic encephalitis, but one had autoimmune limbic encephalitis with no malignancy; two patients had subacute cerebellar degeneration; three had Stiff-person syndrome; one had Lambert-Eaton myasthenic syndrome; and the remaining patient had sensory neuronopathy. In most patients, the neurologic disorder develops before the cancer becomes clinically overt and the patient is referred to a neurologist. Five of our patients' malignancies had been diagnosed in our clinic after their neurologic symptoms became overt. PNS are more common than expected and neurologists should be aware of the variety of the clinical presentations of these syndromes. When physicians suspect PNS, cancer screening should be conducted. The screening must continue even if the results are negative. Keywords: Paraneoplastic, neurologic syndromes, neurogenic autoantibodies Paraneoplastik norolojik sendromlar (PNS), kanserin dogrudan, metastaz ya da tedavi yan etkisine bagli olmayan, uzak etkisi ile ortaya cikan nadir hastaliklardir. Dokuz PNS'li hastanin ikisi limbik ensefalitti fakat bunlardan biri otoimmun limbik ensefalitti ve malignitesi yoktu. Ikisi subakut serebellar dejenerasyon, ucu Stiff-person sendromu, biri Lambert-Eaton miyastenik sendromu digeri ise duyusal noronopatiydi. Bircok hastanin norolojik bulgusu kanserden once gelisir ve norologa yonlendirilir. Bizim de bes hastamiz malignite tanisini bizim klinigimizde aldi. PNS sanilandan daha siktir ve norologlar bu sendromlari akilda bulundurmalidir. PNS'den suphelenildiginde mutlaka kanser taramasi yapilmali ve sonuclar negatif gelse de tarama surdurulmelidir. Anahtar Kelimeler: Paraneoplastik, norolojik sendromlar, norojenik otoantikorlar |
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ISSN: | 1301-062X |
DOI: | 10.4274/tnd.05900 |