Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly en Linea de Celulas Tumorales Resistentes a Quimioterapia

Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lact...

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Bibliographic Details
Published in:International journal of morphology 2017-06, Vol.35 (2), p.733
Main Authors: Roa, Ignacio, Cantin, Mario, Vilos, Cristian, Rosas, Carlos, Lemus, David
Format: Article
Language:Spanish
Subjects:
Angiogenesis inhibitors
Apoptosis
Cancer
Celecoxib
Chemotherapy
COX-2 inhibitors
Health aspects
Vascular endothelial growth factor
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Summary:Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor model induced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferation in addition to increased apoptosis (P
ISSN:0717-9367