Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring

A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2018-03, Vol.51 (12), p.1111-1118
Main Authors: Rodina, T. A., Mel’nikov, E. S., Dmitriev, A. I., Belkov, S. A., Sokolov, A. V., Arkhipov, V. V., Prokof’ev, A. B.
Format: Article
Language:English
Subjects:
Biological products
Bisoprolol
Health aspects
High performance liquid chromatography
Medical schools
Medicine
Metoprolol
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3
cites cdi_FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3
container_end_page 1118
container_issue 12
container_start_page 1111
container_title Pharmaceutical chemistry journal
container_volume 51
creator Rodina, T. A.
Mel’nikov, E. S.
Dmitriev, A. I.
Belkov, S. A.
Sokolov, A. V.
Arkhipov, V. V.
Prokof’ev, A. B.
description A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.
doi_str_mv 10.1007/s11094-018-1750-4
format article
fullrecord <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A535531426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A535531426</galeid><sourcerecordid>A535531426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3</originalsourceid><addsrcrecordid>eNp9kU1LxDAQhoMouH78AG8Bz3FnmqbdHnX9WGEXhVXwFtI0WSJtsibtwX9vl9WDIDKHYYb3mWHmJeQC4QoBymlChCpngDOGpQCWH5AJipKzCjgekglAhQwFvB2Tk5TeAUaKZxPysXbd0PbKmzAkemt6EzvnVe-Cp8HSlenDNoY2tFT5ht649FM6TxdDpzxdmzh0tP6ki-flnK3W09Wa2hDpvHXeadXS2zhs6Cp414fo_OaMHFnVJnP-nU_J6_3dy3zBlk8Pj_PrJdNciJ5l-cwUtaiENhVXZlZWqNHWVlWFEE0JDTYzhRkq4EpY3SC3UNscsSqgUHXDT8nlfu5GtUY6b0Mfle5c0vJajCs45lkxqq7-UI3RmM7p4I11Y_8XgHtAx5BSNFZuo-tU_JQIcmeF3FshRyvkzgqZj0y2Z9J29wET5XsYoh-v_wf6AssAi1s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring</title><source>Springer Nature</source><creator>Rodina, T. A. ; Mel’nikov, E. S. ; Dmitriev, A. I. ; Belkov, S. A. ; Sokolov, A. V. ; Arkhipov, V. V. ; Prokof’ev, A. B.</creator><creatorcontrib>Rodina, T. A. ; Mel’nikov, E. S. ; Dmitriev, A. I. ; Belkov, S. A. ; Sokolov, A. V. ; Arkhipov, V. V. ; Prokof’ev, A. B.</creatorcontrib><description>A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-018-1750-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biological products ; Bisoprolol ; Health aspects ; High performance liquid chromatography ; Medical schools ; Medicine ; Metoprolol ; Organic Chemistry ; Pharmacology/Toxicology ; Pharmacy</subject><ispartof>Pharmaceutical chemistry journal, 2018-03, Vol.51 (12), p.1111-1118</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3</citedby><cites>FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Rodina, T. A.</creatorcontrib><creatorcontrib>Mel’nikov, E. S.</creatorcontrib><creatorcontrib>Dmitriev, A. I.</creatorcontrib><creatorcontrib>Belkov, S. A.</creatorcontrib><creatorcontrib>Sokolov, A. V.</creatorcontrib><creatorcontrib>Arkhipov, V. V.</creatorcontrib><creatorcontrib>Prokof’ev, A. B.</creatorcontrib><title>Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.</description><subject>Biological products</subject><subject>Bisoprolol</subject><subject>Health aspects</subject><subject>High performance liquid chromatography</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Metoprolol</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LxDAQhoMouH78AG8Bz3FnmqbdHnX9WGEXhVXwFtI0WSJtsibtwX9vl9WDIDKHYYb3mWHmJeQC4QoBymlChCpngDOGpQCWH5AJipKzCjgekglAhQwFvB2Tk5TeAUaKZxPysXbd0PbKmzAkemt6EzvnVe-Cp8HSlenDNoY2tFT5ht649FM6TxdDpzxdmzh0tP6ki-flnK3W09Wa2hDpvHXeadXS2zhs6Cp414fo_OaMHFnVJnP-nU_J6_3dy3zBlk8Pj_PrJdNciJ5l-cwUtaiENhVXZlZWqNHWVlWFEE0JDTYzhRkq4EpY3SC3UNscsSqgUHXDT8nlfu5GtUY6b0Mfle5c0vJajCs45lkxqq7-UI3RmM7p4I11Y_8XgHtAx5BSNFZuo-tU_JQIcmeF3FshRyvkzgqZj0y2Z9J29wET5XsYoh-v_wf6AssAi1s</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Rodina, T. A.</creator><creator>Mel’nikov, E. S.</creator><creator>Dmitriev, A. I.</creator><creator>Belkov, S. A.</creator><creator>Sokolov, A. V.</creator><creator>Arkhipov, V. V.</creator><creator>Prokof’ev, A. B.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180301</creationdate><title>Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring</title><author>Rodina, T. A. ; Mel’nikov, E. S. ; Dmitriev, A. I. ; Belkov, S. A. ; Sokolov, A. V. ; Arkhipov, V. V. ; Prokof’ev, A. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biological products</topic><topic>Bisoprolol</topic><topic>Health aspects</topic><topic>High performance liquid chromatography</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Metoprolol</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodina, T. A.</creatorcontrib><creatorcontrib>Mel’nikov, E. S.</creatorcontrib><creatorcontrib>Dmitriev, A. I.</creatorcontrib><creatorcontrib>Belkov, S. A.</creatorcontrib><creatorcontrib>Sokolov, A. V.</creatorcontrib><creatorcontrib>Arkhipov, V. V.</creatorcontrib><creatorcontrib>Prokof’ev, A. B.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodina, T. A.</au><au>Mel’nikov, E. S.</au><au>Dmitriev, A. I.</au><au>Belkov, S. A.</au><au>Sokolov, A. V.</au><au>Arkhipov, V. V.</au><au>Prokof’ev, A. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2018-03-01</date><risdate>2018</risdate><volume>51</volume><issue>12</issue><spage>1111</spage><epage>1118</epage><pages>1111-1118</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-018-1750-4</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0091-150X
ispartof Pharmaceutical chemistry journal, 2018-03, Vol.51 (12), p.1111-1118
issn 0091-150X
1573-9031
language eng
recordid cdi_gale_infotracmisc_A535531426
source Springer Nature
subjects Biological products
Bisoprolol
Health aspects
High performance liquid chromatography
Medical schools
Medicine
Metoprolol
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
title Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T02%3A39%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Simultaneous%20Determination%20of%20Metoprolol%20and%20Bisoprolol%20in%20Human%20Serum%20by%20HPLC-MS/MS%20for%20Clinical%20Drug%20Monitoring&rft.jtitle=Pharmaceutical%20chemistry%20journal&rft.au=Rodina,%20T.%20A.&rft.date=2018-03-01&rft.volume=51&rft.issue=12&rft.spage=1111&rft.epage=1118&rft.pages=1111-1118&rft.issn=0091-150X&rft.eissn=1573-9031&rft_id=info:doi/10.1007/s11094-018-1750-4&rft_dat=%3Cgale_cross%3EA535531426%3C/gale_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c355t-248e6b595ce93ae8791c1fbfa9655d70d1d8a121a03a5fcd13f0bf4119606abd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A535531426&rfr_iscdi=true