Antibacterial Potential Assessment of Schiff Bases Derived from 1-Aminoanthracene-9, 10-Dione

A variety of Schiff bases 1-17 of 1-aminoanthracene-9, 10-dione were synthesized using a reported catalytic method and evaluated for their antibacterial potential against Staphylococcus aureus multidrug resistant (MDR), Escherichia coli (MDR), Klebsiella species (MDR), Salmonella typhimurium (MDR),...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan journal of scientific and industrial research. Series A: physical sciences 2018-01, Vol.61 (1), p.15-18
Main Authors: Fareed, Ghulam, Khan, Fouzia, Fareed, Nazia, Kazmi, Shahana Urooj
Format: Article
Language:English
Subjects:
Analysis
Gram-negative bacteria
Gram-positive bacteria
Microbial drug resistance
Schiff bases
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A variety of Schiff bases 1-17 of 1-aminoanthracene-9, 10-dione were synthesized using a reported catalytic method and evaluated for their antibacterial potential against Staphylococcus aureus multidrug resistant (MDR), Escherichia coli (MDR), Klebsiella species (MDR), Salmonella typhimurium (MDR), Pseudomonas aeruginosa (MDR), Escherichia coli ATCC-8739, Staphylococcus aureus ATCC-25923, Staphylococcus aureus, Escherichia coli, Klebsiella species and Pseudomonas aeruginosa. Compounds 2, 3, 4, 13 and 14 were found to be potent against (MDR) bacterial strains when compared with the cefotaxime standard, however compound 8 exhibited good activities against S. aureus and Klebsiella species. Compounds 2 and 15 were found to be good to moderately active against P. aeruginosa and compounds 4 and 15 demonstrated moderate activity against S. aureus. All the remaining compounds except 11 and 17 showed weak antimicrobial activity against non-MDR strains of bacterial isolates. Keywords: Schiff base, 1-aminoanthracenedione, antibacterial activity, multidrug resistant
ISSN:2221-6413
2223-2559
DOI:10.52763/PJSIR.PHYS.SCI.61.1.2018.15.18