Preparation and biodistribution of .sup.131I-labeled graphene quantum dots

For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labeled with .sup.131I. The in vitro properties, biodistribution and SPECT imaging of .sup.131I-G...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2018-05, Vol.316 (2), p.685
Main Authors: Song, Hu, Wang, Yunhan, Wang, Jing, Wang, Guanquan, He, Jiaheng, Wei, Hongyuan, Luo, Shunzhong
Format: Article
Language:English
Subjects:
Drug delivery systems
Graphene
Graphite
Nuclear physics
Permeability
Single photon emission computed tomography
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Summary:For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labeled with .sup.131I. The in vitro properties, biodistribution and SPECT imaging of .sup.131I-GQDs were investigated. The uptake of .sup.131I-GQDs at tumor sites can be clearly observed via SPECT imaging and T/B and T/M ratios increase with increasing time, which can contribute to enhanced permeability and retention (EPR) effect.
ISSN:0236-5731
DOI:10.1007/s10967-018-5804-6