Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H 2 O. The solubility and dissolution rate of indomethacin from SDs i...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2018-06, Vol.52 (3), p.241-244
Main Authors: Krasnyuk, I. I., Kosheleva, T. M., Belyatskaya, A. V., Stepanova, O. I., Skovpen, Yu, Grikh, V. V., Ovsyannikova, L. V.
Format: Article
Language:English
Subjects:
Indomethacin
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polyethylene glycol
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Summary:Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H 2 O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1799-0