Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations

Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve ( AUC ) and maximum concentration ( C max ) are calcu...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2018-06, Vol.52 (3), p.195-197
Main Authors: Eremenko, N. N., Shikh, E. V., Serebrova, S. Yu, Goryachev, D. V.
Format: Article
Language:English
Subjects:
Medical research
Medicine
Organic Chemistry
Parathyroid hormones
Pharmacology/Toxicology
Pharmacy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve ( AUC ) and maximum concentration ( C max ) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1789-2