Comparison of corifollitropin alfa and daily recombinant follicle-stimulating hormone in poor responder patients undergoing in vitro fertilization cycles/ Dusuk over yanitli hasta grubunda corifollitropin alfa ve rekombinant folikul uyarici hormonun in vitro fertilizasyon sikluslarinda karsilastirilmasi

• Published in: Turkish journal of obstetrics and gynecology 2017-12, Vol.14 (4), p.199
• Main Authors: Akarsu, Suleyman, Demir, Sibel, Gode, Funda, Isik, Ahmet Zeki
• Format: Article
• Language: English
• Subjects: Care and treatment; Comparative analysis; Development and progression; Female infertility; Fertilization in vitro; Follicle-stimulating hormone; Health aspects; Methods; Physiological aspects; Recombinant molecules
• ISSN: 2149-9322
• DOI: 10.4274/tjod.08634

Objective: The aim of this study was to compare the effect of corifollitropin alfa (CFA) and recombinant follicle-stimulating hormone (rFSH) in poor-responder patients undergoing antagonist cycles. Materials and Methods: The study was a retrospective analysis of the treatment results of 214 poor responder patients who had been admitted to the In Vitro Fertilization Unit of Izmir Medical Park Hospital between November 2014 and November 2016. Intracytoplasmic sperm injections were performed in 38 patients (group 1) with CFA, and the remaining 176 (group 2) with rFSH for controlled ovarian hyperstimulation. Results: The age, body mass index, anti-mullerian hormone level, duration of infertility, duration of induction and antral follicle number were similar in the two groups. There was no difference in the total aspirated oocyte counts, mature oocyte ratio, fertilization rate, implantation rate, and clinical pregnancy rates between the two groups. The implantation rate was 9/38 (23.6%) in group 1 and 42/176 (23.8%) in group 2, whereas the clinical pregnancy rates were 16.3% and 17.2%, respectively Conclusion: No difference was found in terms of oocyte count, fertilization rate, implantation rate, and clinical pregnancy rates of CFA or rFSH use in the antagonist cycles in poor-responder patients. Keywords: Corifollitropin alfa, diminished ovarian reserve, gonadotropin-releasing hormone antagonist, in vitro fertilization, poor responder Oz Amac: Bu calismanin amaci dusuk over yanitli hasta grubunda antagonist sikluslarda korifollitropin alfa (CFA) ve rekombinant folikul stimulant hormonun (rFSH) etkinligini karsilastirmakti. Gerec ve Yontemler: Calisma Izmir Medical Park Hastanesi In Vitro Fertilizasyonu Merkezi'nde Kasim 2014 ile Kasim 2016 tarihleri arasinda dusuk over yanitli toplam 214 hastanin kayitlarindan retrospektif olarak yapildi. Otuz sekiz hastaya CFA (grup 1), 176 hastaya (grup 2) rFSH kulanilarak kontrollu ovaryan stimulasyon yapildi. Bulgular: Yas, vucut kitle indeksi, anti-mullerian hormon duzeyi, infertilite suresi, induksiyon suresi ve antral follikul sayisi her iki grupta ayniydi. Aspire edilen toplam oosit sayisi, matur oosit orani, fertilizasyon orani, implantasyon orani ve klinik gebelik orani acisindan her iki grup arasinda fark gozlenmedi. Implantasyon orani grup 1'de 9/38 (%23,6) ve grup 2'de 42/176 (%23,8) iken; klinik gebelik orani sirasiyle grup 1'de %16,3 ve grup 2'de %17,2 idi. Sonuc: Dusuk over yanitli hasta gruplarinda yapilan ant