Analysis of the Association of TNF -238GA Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia

We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this d...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.674
Main Authors: Malysheva, I.E, Topchieva, L.V, Balan, O.V, Marusenko, I.M, Barysheva, O.Yu, Kurbatova, I.V
Format: Article
Language:English
Subjects:
Arthritis
Genes
Genetic aspects
Genetic polymorphisms
Rheumatoid factor
RNA
Tumor necrosis factor
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Summary:We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele. Key Words: rheumatoid arthritis; cytokines; TNF gene; polymorphism; expression
ISSN:0007-4888
DOI:10.1007/s10517-018-4239-y