Association of a single nucleotide polymorphism in the TLR2 gene , with Helicobacter pylori infection and peptic ulcer

Background/Aims: Toll-like receptors (TLRs), particularly TLR2 and TLR4, take part in elicitation of immune responses against Helicobacter pylori (H. pylori). This study aimed to investigate the relationship between single nucleotide polymorphisms (SNP) rs3804099 in the TLR2 gene and rs4986 790 in t...

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Bibliographic Details
Published in:The Turkish journal of gastroenterology 2018-05, Vol.29 (3), p.283
Main Authors: Mirkamandar, Ehsan, Nemati, Maryam, Hayatbakhsh, Mohammad Mehdi, Bassagh, Arezu, Khosravimashizi, Arezu, Jafarzadeh, Abdollah
Format: Article
Language:English
Subjects:
Gene expression
Genetic aspects
Helicobacter infections
Peptic ulcer
Single nucleotide polymorphisms
Online Access:Get full text
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Summary:Background/Aims: Toll-like receptors (TLRs), particularly TLR2 and TLR4, take part in elicitation of immune responses against Helicobacter pylori (H. pylori). This study aimed to investigate the relationship between single nucleotide polymorphisms (SNP) rs3804099 in the TLR2 gene and rs4986 790 in the TLR4 gene with H. pylori infection and peptic ulcer (PU). Materials and Methods: Blood specimens were obtained from 350 individuals, including 100 H. pylori-infected patients with PU, 125 H. pylori-infected asymptomatic subjects (AS), and 125 non-infected healthy subjects (NHS). The DNA was extracted, and the SNPs were determined using ARMS-PCR method. Results: The frequency of CT genotype at TLR2 SNP rs3804099 in both the PU and AS groups was significantly higher than in the NHS group (p
ISSN:1300-4948
DOI:10.5152/tjg.2018.17484