Molecular and cellular oncogenic mechanisms in hepatocellular carcinoma. (RESEARCH)

Hepatocellular carcinoma (HCC), as the fifth most diagnosed cancer in the world and the third leading cause of death, is a global health concern. Research stimulated by the dismal prognosis of HCC has led to significant advances in the understanding of its aetio-pathogenesis. Dysregulation of geneti...

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Bibliographic Details
Published in:South African medical journal 2018-08, Vol.108 (8 S1), p.S41
Main Authors: Setshedi, M, Andersson, M, Kgatle, M.M, Roberts, L.R
Format: Article
Language:English
Subjects:
Carcinogenesis
Care and treatment
Gene mutation
Genetic aspects
Health aspects
Hepatocellular carcinoma
Liver research
Oncogenes
Physiological aspects
Signaling peptides and proteins
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Summary:Hepatocellular carcinoma (HCC), as the fifth most diagnosed cancer in the world and the third leading cause of death, is a global health concern. Research stimulated by the dismal prognosis of HCC has led to significant advances in the understanding of its aetio-pathogenesis. Dysregulation of genetic, epigenetic and signalling pathways as well as tumour immunological escape mechanisms are implicated in the development of HCC. This review summarises the current knowledge of these mechanisms and argues that it is only through further understanding of their role in hepatocarcinogenesis, that new effective therapies can be developed. DOI:10.7196/SAMJ.2018.v108i8.13500
ISSN:0256-9574
DOI:10.7196/SAMJ.2018.v108i8.13500