DIAGNOSTIC VALUE OF COGNITIVE-REGISTRATION MULTIPARAMETRIC MAGNETIC RESONANCE GUIDED BIOPSY FOR THE DETECTION OF PROSTATE CANCER AFTER INITIAL NEGATIVE BIOPSY/DIJAGNOSTICKI ZNACAJ BIOPSIJE PROSTATE VODENE KOGNITIVNOM FUZIJOM MULTIPARAMETRIJSKE MAGNETNE REZONANCE I TRANSREKTALNOG ULTRAZVUKA KOD BOLESNIKA S PRETHODNO NEGATIVNOM TRUS VODENOM BIOPSIJOM

• Published in: Acta clinica Croatica (Tisak) 2018-03, Vol.57 (S1), p.40
• Main Authors: Tomaskovic, Igor, Pezelj, Ivan, Culo, Karolina Bolanca, Novosel, Luka, Nikles, Sven, Tomic, Miroslav, Reljic, Ante, Katusic, Josip, Knezevic, Matej, Pirsa, Matea, Kruslin, Bozo, Ulamec, Monika, Ruzic, Boris
• Format: Article
• Language: English
• Subjects: Analysis; Diagnosis; Health aspects; Magnetic resonance imaging; Measurement; Prostate biopsy; Prostate cancer; Prostate specific antigen; Prostate ultrasonography
• ISSN: 0353-9466
• DOI: 10.20471/acc.2018.57.s1.05

The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017, in 101 consecutive patients with elevated antigen (PSA) and/or positive digital rectal examination and after a negative first TRUS biopsy, a second, repeated prostate biopsy was performed. In 24 patients, cognitive fusion mpMRI-TRUS biopsy of the prostate with 8-10 system cores and 1-3 target biopsies was performed, in line with the European Association of Urology guidelines. In 77 patients, only a classic, repeated TRUS guided biopsy was performed. In patients with mpMRI, the detection rate according to PIRADS-v2 reporting system was: PIRADS 1, n = 0; PIRADS 2, n = 0; PIRADS 3, n = 0; PIRADS 4, n = 6/8 (75%); and PIRADS 5, n = 2/3 (67%). In the group of patients with MR-TRUS cognitive fusion biopsy, the prostate cancer detection rate was 8/24 (33%), while in the control group the detection rate was 12/77 (16%), which was statistically significant (t test, p = 0.037, CI 95% is 0.01 to 0.37). Patients with PIRADS [less than or equal to] 3 (54%) could have avoided the biopsy.Key words: Prostate cancer; Multiparametric magnetic resonance; BiopsyU ovoj prospektivnoj klinickoj studiji cilj je odrediti stopu detekcije raka prostate biopsije vodene kognitivnom fuzijom multiparametrijske magnetne rezonance i transrektalnog ultrazvuka (mpMRI-TRUS) kod bolesnika s prethodno negativnom TRUS vodenom biopsijom. U razdoblju od 1. 10. 2016. do 1. 7. 2017. kod 101 uzastopnog bolesnika s povisenim prostata specificnim antigenom (PSA) i/ili pozitivnim digitorektalnim pregledom, a nakon negativne prve TRUS biopsije je ucinjena druga, ponovljena biopsija prostate. Kod 24 bolesnika ucinjena je, u skladu sa Smjernicama Europskog uroloskog drustva, prethodna mpMRI i potom kognitivna fuzijska biopsija prostate s 8-10 sistemskih cilindara i 1-3 ciljane biopsije prema mpMRI nalazu. Kod 77 bolesnika je ucinjena samo klasicna, ponovljena TRUS biopsija bez prethodne slikovne obrade. Kod bolesnika s mpMRI, stopa detekcije raka prema PIRADSU-v2 je PIRADS 1, n = 0; PIRADS 2, n = 0; PIRADS 3, n = 0; PIRADS 4, n = 6/8 (75%) i PIRADS 5, n = 2/3 (67%). U skupini bolesnika s MR-TRUS kognitivnom fuzijskom biopsijom stopa detekcije raka prostate je 8/24 (33%), dok je u kontrolnoj skupini stopa dete