Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients/Perfil de acidos graxos nos eritrocitos associados com citocinas sericas em pacientes pediatricos com Fibrose Cistica

To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fib...

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Published in:Revista de nutrição 2018-09, Vol.31 (5), p.455
Main Authors: Cunha, Ana Lucia Pereira da, Costa, Ana Carolina Carioca da, Vasconcelos, Zilton, Carmo, Maria Das Gracas Tavares Do, Chaves, Celia Regina Moutinho de Miranda
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container_title Revista de nutrição
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Costa, Ana Carolina Carioca da
Vasconcelos, Zilton
Carmo, Maria Das Gracas Tavares Do
Chaves, Celia Regina Moutinho de Miranda
description To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-a, IL-1 [beta], IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of
doi_str_mv 10.1590/1678-98652018000500003
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A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-a, IL-1 [beta], IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-a was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1 [beta] and IL-6 was observed (p<0.05). The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis Analisar a composicao dos acidos graxos nos eritrocitos e sua associacao com os niveis sericos de citocinas em pacientes pediatricos com fibrose cistica. Foram estudadas 26 criancas (<10 anos) e 31 adolescentes, sendo a maioria do sexo feminino, heterozigoto para a mutacao DF508 e com insuficiencia pancreatica exocrina. Nas criancas e nos adolescentes as concentracoes de acido graxo linoleico eram baixas (<21%). O TNF-a foi o unico marcador pro-infiamatorio cujas concentracoes estavam aumentadas, principalmente nas criancas. Uma associacao entre a composicao de acidos graxos nos eritrocitos e as citocinas IL-1[beta] e IL-6 foi observada (p<0,05).]]></description><identifier>ISSN: 1415-5273</identifier><identifier>DOI: 10.1590/1678-98652018000500003</identifier><language>eng</language><publisher>Pontificia Universidade Catolica de Campinas</publisher><ispartof>Revista de nutrição, 2018-09, Vol.31 (5), p.455</ispartof><rights>COPYRIGHT 2018 Pontificia Universidade Catolica de Campinas</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Cunha, Ana Lucia Pereira da</creatorcontrib><creatorcontrib>Costa, Ana Carolina Carioca da</creatorcontrib><creatorcontrib>Vasconcelos, Zilton</creatorcontrib><creatorcontrib>Carmo, Maria Das Gracas Tavares Do</creatorcontrib><creatorcontrib>Chaves, Celia Regina Moutinho de Miranda</creatorcontrib><title>Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients/Perfil de acidos graxos nos eritrocitos associados com citocinas sericas em pacientes pediatricos com Fibrose Cistica</title><title>Revista de nutrição</title><description><![CDATA[To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-a, IL-1 [beta], IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-a was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1 [beta] and IL-6 was observed (p<0.05). The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis Analisar a composicao dos acidos graxos nos eritrocitos e sua associacao com os niveis sericos de citocinas em pacientes pediatricos com fibrose cistica. Foram estudadas 26 criancas (<10 anos) e 31 adolescentes, sendo a maioria do sexo feminino, heterozigoto para a mutacao DF508 e com insuficiencia pancreatica exocrina. Nas criancas e nos adolescentes as concentracoes de acido graxo linoleico eram baixas (<21%). O TNF-a foi o unico marcador pro-infiamatorio cujas concentracoes estavam aumentadas, principalmente nas criancas. Uma associacao entre a composicao de acidos graxos nos eritrocitos e as citocinas IL-1[beta] e IL-6 foi observada (p<0,05).]]></description><issn>1415-5273</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkM9OwzAMxnMAifHnFVAkzmVJS7b2iCYqjhy4TyF1N0PbVLER9GV5Ftxp2nkH67PsT9_PslL31jxaV5mlXa3LrCpXLje2NMY4KVNcqIV9si5z-bq4UtdEn8ZIW7mF-qs986R9wEaPKbbYgcZBQ5p4n2KYGEh7ohjQMzT6B3mvCdJ3r2UXv3CQvfhHaMSQMMiYWKTFjxQJSY-eEQam5RskSdcNHGCR9C75X5FBChKy0JDjiTY7QhSMDAMOnmYsBlHoJTTMocI-gY_2-sAFvcH5DH-rLlvfEdwd9UY91C_vm9ds5zvY4tBGTj70SGH77EprcnlYWZzn-gdl73rO</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Cunha, Ana Lucia Pereira da</creator><creator>Costa, Ana Carolina Carioca da</creator><creator>Vasconcelos, Zilton</creator><creator>Carmo, Maria Das Gracas Tavares Do</creator><creator>Chaves, Celia Regina Moutinho de Miranda</creator><general>Pontificia Universidade Catolica de Campinas</general><scope>INF</scope></search><sort><creationdate>20180901</creationdate><title>Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients/Perfil de acidos graxos nos eritrocitos associados com citocinas sericas em pacientes pediatricos com Fibrose Cistica</title><author>Cunha, Ana Lucia Pereira da ; Costa, Ana Carolina Carioca da ; Vasconcelos, Zilton ; Carmo, Maria Das Gracas Tavares Do ; Chaves, Celia Regina Moutinho de Miranda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracmisc_A5810250083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cunha, Ana Lucia Pereira da</creatorcontrib><creatorcontrib>Costa, Ana Carolina Carioca da</creatorcontrib><creatorcontrib>Vasconcelos, Zilton</creatorcontrib><creatorcontrib>Carmo, Maria Das Gracas Tavares Do</creatorcontrib><creatorcontrib>Chaves, Celia Regina Moutinho de Miranda</creatorcontrib><collection>Informe Académico</collection><jtitle>Revista de nutrição</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunha, Ana Lucia Pereira da</au><au>Costa, Ana Carolina Carioca da</au><au>Vasconcelos, Zilton</au><au>Carmo, Maria Das Gracas Tavares Do</au><au>Chaves, Celia Regina Moutinho de Miranda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients/Perfil de acidos graxos nos eritrocitos associados com citocinas sericas em pacientes pediatricos com Fibrose Cistica</atitle><jtitle>Revista de nutrição</jtitle><date>2018-09-01</date><risdate>2018</risdate><volume>31</volume><issue>5</issue><spage>455</spage><pages>455-</pages><issn>1415-5273</issn><abstract><![CDATA[To analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fibrosis patients. A cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-a, IL-1 [beta], IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. Twenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-a was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1 [beta] and IL-6 was observed (p<0.05). The pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis Analisar a composicao dos acidos graxos nos eritrocitos e sua associacao com os niveis sericos de citocinas em pacientes pediatricos com fibrose cistica. Foram estudadas 26 criancas (<10 anos) e 31 adolescentes, sendo a maioria do sexo feminino, heterozigoto para a mutacao DF508 e com insuficiencia pancreatica exocrina. Nas criancas e nos adolescentes as concentracoes de acido graxo linoleico eram baixas (<21%). O TNF-a foi o unico marcador pro-infiamatorio cujas concentracoes estavam aumentadas, principalmente nas criancas. Uma associacao entre a composicao de acidos graxos nos eritrocitos e as citocinas IL-1[beta] e IL-6 foi observada (p<0,05).]]></abstract><pub>Pontificia Universidade Catolica de Campinas</pub><doi>10.1590/1678-98652018000500003</doi></addata></record>
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title Fatty acid profile in erythrocytes associated with serum cytokines in pediatric cystic fibrosis patients/Perfil de acidos graxos nos eritrocitos associados com citocinas sericas em pacientes pediatricos com Fibrose Cistica
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